SARS-CoV-2 immunity in animal models

Z Chen, Y Yuan, Q Hu, A Zhu, F Chen, S Li… - Cellular & molecular …, 2024 - nature.com
The COVID-19 pandemic, which was caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its …

[HTML][HTML] Organoids and organoids-on-a-chip as the new testing strategies for environmental toxicology-applications & advantages

C Hu, S Yang, T Zhang, Y Ge, Z Chen, J Zhang… - Environment …, 2024 - Elsevier
An increasing number of harmful environmental factors are causing serious impacts on
human health, and there is an urgent need to accurately identify the toxic effects and …

Single-molecule force stability of the SARS-CoV-2–ACE2 interface in variants-of-concern

MS Bauer, S Gruber, A Hausch, MCR Melo… - Nature …, 2024 - nature.com
Mutations in SARS-CoV-2 have shown effective evasion of population immunity and
increased affinity to the cellular receptor angiotensin-converting enzyme 2 (ACE2) …

[HTML][HTML] Formation and function of multiciliated cells

Q Lyu, Q Li, J Zhou, H Zhao - Journal of Cell Biology, 2024 - rupress.org
In vertebrates, multiciliated cells (MCCs) are terminally differentiated cells that line the
airway tracts, brain ventricles, and reproductive ducts. Each MCC contains dozens to …

Omicron Spike confers enhanced infectivity and interferon resistance to SARS-CoV-2 in human nasal tissue

G Shi, T Li, KK Lai, RF Johnson, JW Yewdell… - Nature …, 2024 - nature.com
Omicron emerged following COVID-19 vaccination campaigns, displaced previous SARS-
CoV-2 variants of concern worldwide, and gave rise to lineages that continue to spread …

Comparative Pathogenesis of Severe Acute Respiratory Syndrome Coronaviruses

J Zhang, M Rissmann, T Kuiken… - Annual Review of …, 2024 - annualreviews.org
Over the last two decades the world has witnessed the global spread of two genetically
related highly pathogenic coronaviruses, severe acute respiratory syndrome coronavirus …

[HTML][HTML] Glycan-directed SARS-CoV-2 inhibition by leek extract and lectins with insights into the mode-of-action of Concanavalin A

M Klevanski, H Kim, M Heilemann, T Kuner… - Antiviral Research, 2024 - Elsevier
Four years after its outbreak, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) remains a global challenge for human health. At its surface, SARS-CoV-2 features …

Network-based analysis between SARS-CoV-2 receptor ACE2 and common host factors in COVID-19 and asthma: Potential mechanistic insights

Q Yan, XY Lin, CW Peng, WJ Zheng, XH Liu… - … Signal Processing and …, 2024 - Elsevier
ACE2 as a functional receptor for SARS coronavirus plays an important role in COVID-19
infection of the host. Thus, we aimed to explore interaction networks between ACE2 and …

Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy (PAR-SIM)

X Xu, W Wang, L Qiao, Y Fu, X Ge, K Zhao… - Light: Science & …, 2024 - nature.com
Structured illumination microscopy (SIM) has emerged as a promising super-resolution
fluorescence imaging technique, offering diverse configurations and computational …

SARS-CoV-2 variant of concern fitness and adaptation in primary human airway epithelia

RM Meganck, CE Edwards, ML Mallory, RE Lee… - Cell Reports, 2024 - cell.com
The severe acute respiratory syndrome coronavirus 2 pandemic is characterized by the
emergence of novel variants of concern (VOCs) that replace ancestral strains. Here, we …