Structure–function of type I and III interferons
NA de Weerd, AK Kurowska, JL Mendoza… - Current Opinion in …, 2024 - Elsevier
Type I and type III interferons (IFNs) are major components in activating the innate immune
response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and …
response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and …
Location, location, location: Protein kinase nanoclustering for optimised signalling output
Protein kinases (PKs) are proteins at the core of cellular signalling and are thereby
responsible for most cellular physiological processes and their regulations. As for all …
responsible for most cellular physiological processes and their regulations. As for all …
A novel approach to study multi-domain motions in JAK1's activation mechanism based on energy landscape
S Sun, G Rodriguez, G Zhao, JE Sanchez… - Briefings in …, 2024 - academic.oup.com
Abstract The family of Janus Kinases (JAKs) associated with the JAK–signal transducers
and activators of transcription signaling pathway plays a vital role in the regulation of various …
and activators of transcription signaling pathway plays a vital role in the regulation of various …
Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin
Thrombopoietin (Tpo) is the primary regulator of megakaryocyte and platelet numbers and is
required for haematopoetic stem cell maintenance. Tpo functions by binding its receptor …
required for haematopoetic stem cell maintenance. Tpo functions by binding its receptor …
Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling
BG Abraham, T Haikarainen, J Vuorio, M Girych… - Science …, 2024 - science.org
Janus kinase 2 (JAK2) mediates type I/II cytokine receptor signaling, but JAK2 is also
activated by somatic mutations that cause hematological malignancies by mechanisms that …
activated by somatic mutations that cause hematological malignancies by mechanisms that …
Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling
Cytokines regulate immune responses by binding to cell surface receptors, including the
common subunit beta (βc), which mediates signaling for GM-CSF, IL-3, and IL-5. Despite …
common subunit beta (βc), which mediates signaling for GM-CSF, IL-3, and IL-5. Despite …
Correlative single-molecule and structured illumination microscopy of fast dynamics at the plasma membrane
Total internal reflection fluorescence (TIRF) microscopy offers powerful means to uncover
the functional organization of proteins in the plasma membrane with very high spatial and …
the functional organization of proteins in the plasma membrane with very high spatial and …
Single-Molecule Imaging of Integral Membrane Protein Dynamics and Function
Integral membrane proteins (IMPs) play central roles in cellular physiology and represent
the majority of known drug targets. Single-molecule fluorescence and fluorescence …
the majority of known drug targets. Single-molecule fluorescence and fluorescence …
Myeloproliferative Neoplasms: Diseases Mediated by Chronic Activation of Signal Transducer and Activator of Transcription (STAT) Proteins
C Liongue, AC Ward - Cancers, 2024 - mdpi.com
Simple Summary A group of blood diseases called myeloproliferative neoplasms (MPNs)
cause a buildup of certain blood cell types in affected individuals. Each MPN category has a …
cause a buildup of certain blood cell types in affected individuals. Each MPN category has a …
Exploring the landscape of synthetic IL‐6‐type cytokines
J Scheller, J Ettich, C Wittich, S Pudewell… - The FEBS …, 2024 - Wiley Online Library
Interleukin‐6 (IL‐6)‐type cytokines not only have key immunomodulatory functions that affect
the pathogenesis of diseases such as autoimmune diseases, chronic inflammatory …
the pathogenesis of diseases such as autoimmune diseases, chronic inflammatory …