Novel preclinical developments of the primary sclerosing cholangitis treatment landscape

A Sohal, KV Kowdley - Expert Opinion on Investigational Drugs, 2024 - Taylor & Francis
Introduction Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease
associated with inflammation, fibrosis, and destruction of intra-and extrahepatic bile ducts …

[HTML][HTML] Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis

J Leighton, DEJ Jones, JK Dyson… - BMC Medical …, 2024 - ncbi.nlm.nih.gov
Abstract Primary Sclerosing Cholangitis (PSC) is a progressive cholestatic liver disease with
no licensed therapies. Previous Genome Wide Association Studies (GWAS) have identified …

Hepatobiliary Disease

ME Gerich, EV Loftus - Clinical Challenges and Complications of …, 2024 - taylorfrancis.com
The interaction between inflammatory bowel disease (IBD) and liver disease was first
described more than 100 years ago. 1 Although previously believed to be rare, hepatobiliary …

Medical Management of Extraintestinal Manifestations of Ulcerative Colitis

L Mayer, R Pittman - Ulcerative Colitis, 2024 - taylorfrancis.com
The inflammatory bowel diseases (IBDs) are a group of intestinal disorders with specific
features that share the potential to become systemic. The systemic nature of these …

Is Ursodeoxycholic Acid Effective for the Treatment of Primary Sclerosing Cholangitis?

BM Reid, VA Luketic - Curbside Consultation of the Liver, 2024 - taylorfrancis.com
Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease characterized
by inflammation and obliterative fibrosis of the intrahepatic and extrahepatic biliary tree. The …