The immunology of type 1 diabetes
KC Herold, T Delong, AL Perdigoto, N Biru… - Nature Reviews …, 2024 - nature.com
Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …
Cracking the type 1 diabetes code: Genes, microbes, immunity, and the early life environment
C Yau, JS Danska - Immunological Reviews, 2024 - Wiley Online Library
Summary Type 1 diabetes (T1D) results from a complex interplay of genetic predisposition,
immunological dysregulation, and environmental triggers, that culminate in the destruction of …
immunological dysregulation, and environmental triggers, that culminate in the destruction of …
[HTML][HTML] An antigen-specific immunotherapeutic, AKS-107, deletes insulin-specific B cells and prevents murine autoimmune diabetes
DG Alleva, AR Delpero, T Sathiyaseelan… - Frontiers in …, 2024 - frontiersin.org
Introduction The antigen-presenting cell function of insulin-reactive B cells promotes type 1
diabetes (T1D) in non-obese diabetic (NOD) mice by stimulating pathogenic T cells leading …
diabetes (T1D) in non-obese diabetic (NOD) mice by stimulating pathogenic T cells leading …
[HTML][HTML] Factors Governing B Cell Recognition of Autoantigen and Function in Type 1 Diabetes
LE Bass, RH Bonami - Antibodies, 2024 - mdpi.com
Islet autoantibodies predict type 1 diabetes (T1D) but can be transient in murine and human
T1D and are not thought to be directly pathogenic. Rather, these autoantibodies signal B cell …
T1D and are not thought to be directly pathogenic. Rather, these autoantibodies signal B cell …
A Composite Biomarker Signature of Type 1 Diabetes Risk Identified via Augmentation of Parallel Multi-Omics Data from a Small Cohort
O Alcazar, ST Chuang, G Ren, M Ogihara… - bioRxiv, 2024 - biorxiv.org
(1) Background: Biomarkers of early pathogenesis of type 1 diabetes (T1D) are crucial to
enable effective prevention measures in at-risk populations before significant damage …
enable effective prevention measures in at-risk populations before significant damage …
Islet-antigen reactive B cells display a unique phenotype and BCR repertoire in autoantibody positive and recent-onset type 1 diabetes patients
CA Nicholas, FA Tensun, SA Evans, KP Toole… - bioRxiv, 2024 - biorxiv.org
Autoreactive B cells play an important but ill-defined role in autoimmune type 1 diabetes
(T1D). To better understand their contribution, we performed single cell gene and BCR-seq …
(T1D). To better understand their contribution, we performed single cell gene and BCR-seq …