The interplay between obesity, immunosenescence, and insulin resistance
Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human
health. Obesity-related metabolic dysregulation has similarities to the metabolic alterations …
health. Obesity-related metabolic dysregulation has similarities to the metabolic alterations …
[HTML][HTML] Aging, sex, metabolic and life experience factors: contributions to neuro-inflammaging in Alzheimer's disease research
Alzheimer's disease (AD) is prevalent around the world, yet our understanding of the
disease is still very limited. Recent work suggests that the cornerstone of AD may include the …
disease is still very limited. Recent work suggests that the cornerstone of AD may include the …
[HTML][HTML] Using genetics and proteomics data to identify proteins causally related to COVID-19, healthspan and lifespan: a Mendelian randomization study
Background: COVID-19 pandemic poses a heavy burden on public health and accounts for
substantial mortality and morbidity. Proteins are building blocks of life, but specific proteins …
substantial mortality and morbidity. Proteins are building blocks of life, but specific proteins …
Low-molecular-weight heparin ameliorates intestinal barrier dysfunction in aged male rats via protection of tight junction proteins
S Wang, H Yang - Biogerontology, 2024 - Springer
The intestinal barrier weakens and chronic gut inflammation occurs in old age, causing age-
related illnesses. Recent research shows that low-molecular-weight heparin (LMWH) …
related illnesses. Recent research shows that low-molecular-weight heparin (LMWH) …
A Perfect Storm: The Convergence of Aging, Human Immunodeficiency Virus Infection, and Inflammasome Dysregulation
S Thirugnanam, N Rout - Current Issues in Molecular Biology, 2024 - mdpi.com
The emergence of combination antiretroviral therapy (cART) has greatly transformed the life
expectancy of people living with HIV (PWH). Today, over 76% of the individuals with HIV …
expectancy of people living with HIV (PWH). Today, over 76% of the individuals with HIV …
Stress, aging, and inflammation
S Matovic, C Rummel, M Feldotto, JP Gouin - Stress: Immunology and …, 2024 - Elsevier
Aging is associated with the development of chronic low-grade inflammation, a
phenomenon called “inflammaging,” which can be enhanced in the context of chronic stress …
phenomenon called “inflammaging,” which can be enhanced in the context of chronic stress …
Sex and aging signatures of proteomics in human cerebrospinal fluid identify distinct clusters linked to neurodegeneration.
YJ Sung, D Seo, J Timsina, P Kohlfeld, J Morris… - medRxiv, 2024 - medrxiv.org
Sex and age are major risk factors for chronic diseases. Recent studies examining age-
related molecular changes in plasma provided insights into age-related disease biology …
related molecular changes in plasma provided insights into age-related disease biology …
The adaptive response of old ABCB5+ MSCs is changed upon exposure to LPS
P Haas - 2024 - oparu.uni-ulm.de
Old ABCB5+ MSCs reveal a disturbed sensing and adaptive response upon exposure to
LPS accompanied with a prolonged and delayed back-regulation of NF-kB and its target …
LPS accompanied with a prolonged and delayed back-regulation of NF-kB and its target …
[PDF][PDF] Assessment of IL-6, TGF-β1 and CTX-II in the diagnosis of early Post-Traumatic Osteoarthritis of knee.
KR Meenakshisundaram, TK Alwar… - … Journal of Medical …, 2024 - jag.journalagent.com
Objectives: Osteoarthritis is an inflammatory and degenerative disorder characterized by the
degradation of the extracellular matrix. It commences with injuries to the knee that activate …
degradation of the extracellular matrix. It commences with injuries to the knee that activate …