Multi-omics analysis reveals that linoleic acid metabolism is associated with variations of trained immunity induced by distinct BCG strains
JC Xu, ZY Chen, XJ Huang, J Wu, H Huang, LF Niu… - Science …, 2024 - science.org
Trained immunity is one of the mechanisms by which BCG vaccination confers persistent
nonspecific protection against diverse diseases. Genomic differences between the different …
nonspecific protection against diverse diseases. Genomic differences between the different …
Potential impact of bioactive compounds as NLRP3 inflammasome inhibitors: An update
S Singh, S Sharma, H Sharma - Current Pharmaceutical …, 2024 - ingentaconnect.com
The inflammasome NLRP3 comprises a caspase recruitment domain, a pyrin domain
containing receptor 3, an apoptosis-linked protein like a speck containing a procaspase-1 …
containing receptor 3, an apoptosis-linked protein like a speck containing a procaspase-1 …
STING-dependent trained immunity contributes to host defense against Clostridium perfringens infection via mTOR signaling
ZZ Liu, CK Zhou, XQ Lin, Y Gao, XY Luo, JB Zhang… - Veterinary …, 2024 - Springer
Clostridium perfringens (C. perfringens) infection is recognized as one of the most
challenging issues threatening food safety and perplexing agricultural development. To …
challenging issues threatening food safety and perplexing agricultural development. To …
Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis
Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear.
Here, we establish that aging of the immune system, regardless of the age of the stroma and …
Here, we establish that aging of the immune system, regardless of the age of the stroma and …
Unravelling monocyte functions: from the guardians of health to the regulators of disease
Monocytes are a key component of the innate immune system. They undergo intricate
developmental processes within the bone marrow, leading to diverse monocyte subsets in …
developmental processes within the bone marrow, leading to diverse monocyte subsets in …
Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)
HY Kim, YJ Kang, DH Kim, J Jang, SJ Lee, G Kim… - Elife, 2024 - elifesciences.org
Trained immunity is the long-term functional reprogramming of innate immune cells, which
results in altered responses toward a secondary challenge. Despite indoxyl sulfate (IS) …
results in altered responses toward a secondary challenge. Despite indoxyl sulfate (IS) …
Greater adherence to the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet is associated with lower risk …
Background: The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND)
diet is emerging as a promising candidate for preventive measures against inflammatory …
diet is emerging as a promising candidate for preventive measures against inflammatory …
Ischemia does not provoke the full immune training repertoire in human cardiac fibroblasts
C Mann, C van Alst, S Gorressen, R Nega… - Naunyn-Schmiedeberg's …, 2024 - Springer
Trained immunity of monocytes, endothelial, and smooth muscle cells augments the
cytokine response to secondary stimuli. Immune training is characterized by stabilization of …
cytokine response to secondary stimuli. Immune training is characterized by stabilization of …
Low protein diet protects liver function upon Salmonella infection by metabolic reprogramming of macrophages
EE Wojtowicz, K Hampton, M Moreno-Gonzalez… - bioRxiv, 2024 - biorxiv.org
Background & Aims: Western diets are the underlying cause of metabolic and liver diseases.
Recent trend to limit the consumption of protein-rich animal products has become more …
Recent trend to limit the consumption of protein-rich animal products has become more …
Assoziation zwischen einer genetisch-determinierten NLRP3-Inflammasom-vermittelten systemischen Inflammation und kardiovaskulärer Mortalität
IT Jaumann - 2024 - publikationen.sulb.uni-saarland.de
Ziel der Arbeit Inflammation spielt eine wichtige Rolle bei der Entstehung von
kardiovaskulären Erkrankungen. Das NOD-like receptor protein-3 (NLRP3) Inflammasom …
kardiovaskulären Erkrankungen. Das NOD-like receptor protein-3 (NLRP3) Inflammasom …