Precursor lesions in familial and hereditary pancreatic cancer

MJ Pflüger, LAA Brosens, RH Hruban - Familial Cancer, 2024 - Springer
Infiltrating ductal adenocarcinoma of the pancreas, referred to here as “pancreatic cancer,” is
one of the deadliest of all of the solid malignancies. The five-year survival rate in the United …

Long-Term Oncologic Outcome Following Duodenum-Preserving Pancreatic Head Resection for Benign Tumors, Cystic Neoplasms, and Neuroendocrine Tumors …

HG Beger, B Mayer, B Poch - Annals of Surgical Oncology, 2024 - Springer
Background Pancreatoduodenectomy (PD) has a considerable surgical risk for
complications and late metabolic morbidity. Parenchyma-sparing resection of benign tumors …

Gene rearrangement and expression of PRKACA and PRKACB govern morphobiology of pancreatobiliary oncocytic neoplasms

T Itoh, Y Omori, M Seino, K Hirose, F Date, Y Ono… - Modern Pathology, 2024 - Elsevier
Intraductal oncocytic papillary neoplasms (IOPNs) are distinct from intraductal papillary
mucinous neoplasms based on characteristic morphologic and genetic features represented …

Risk of Recurrence After Surgical Resection for Adenocarcinoma Arising From Intraductal Papillary Mucinous Neoplasia (IPMN) With Patterns of Distribution and …

J Lucocq, J Hawkyard, FP Robertson, B Haugk… - Annals of …, 2024 - journals.lww.com
Objective: This international multicenter cohort study aims to identify recurrence patterns and
treatment of first and second recurrence in a large cohort of patients after pancreatic …

Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms

A Agostini, G Piro, F Inzani, G Quero, A Esposito… - Nature …, 2024 - nature.com
Abstract The existing Intraductal Papillary Mucinous Neoplasm (IPMN) risk stratification
relies on clinical and histological factors, resulting in inaccuracies and leading to suboptimal …

Neoplastic Progression in Macroscopic Precursor Lesions of the Pancreas

ED Thompson - Archives of Pathology & Laboratory …, 2024 - meridian.allenpress.com
Context.—Macroscopic precursor lesions of the pancreas represent a complex clinical
management problem. Molecular characterization of pancreatic cysts has helped to confirm …

Targeting KRAS mutations in pancreatic cancer: opportunities for future strategies

A Linehan, M O'Reilly, R McDermott… - Frontiers in Medicine, 2024 - frontiersin.org
Targeting the RAS pathway remains the holy grail of precision oncology. In the case of
pancreatic ductal adenocarcinomas (PDAC), 90–92% harbor mutations in the oncogene …

Pancreatic Cancer Screening among High-risk Individuals

KM Turner, SH Patel - Surgical Clinics, 2024 - surgical.theclinics.com
The incidence of pancreas cancer is estimated to be 66,440 cases in 2024, making it the
10th most common cancer in the United States. 1 Despite its rare nature, mortality rates …

Molecular Pathology of Pancreatic Cystic Lesions with a Focus on Malignant Progression

Y Hu, D Jones, AK Esnakula, SG Krishna, W Chen - Cancers, 2024 - mdpi.com
Simple Summary Pancreatic cysts are being identified with increasing frequency, and the
prevalence increases with age to 10–25% by the 7th decade of life. They also have the …

Pancreas Cyst Diagnosis and Advances in Cyst Fluid Analysis

T Pollini, L Todeschini, AV Maker - Surgical Clinics, 2024 - surgical.theclinics.com
Pancreatic cystic neoplasms are frequently detected in the general population. Among
these, mucinous cysts, specifically intraductal papillary mucinous neoplasms (IPMN) and …