Antibody persistence and safety of a live-attenuated chikungunya virus vaccine up to 2 years after single-dose administration in adults in the USA: a single-arm …
R McMahon, S Toepfer, N Sattler… - The Lancet Infectious …, 2024 - thelancet.com
Background Chikungunya virus infection can lead to long-term debilitating symptoms. A
precursor phase 3 clinical study showed high seroprotection (defined as a 50% plaque …
precursor phase 3 clinical study showed high seroprotection (defined as a 50% plaque …
[HTML][HTML] Chikungunya virus vaccine: a decade of progress solving epidemiological dilemma, emerging concepts, and immunological interventions
MS Shaikh, M Faiyazuddin, MS Khan… - Frontiers in …, 2024 - frontiersin.org
Chikungunya virus (CHIKV), a single-stranded RNA virus transmitted by Aedes mosquitoes,
poses a significant global health threat, with severe complications observed in vulnerable …
poses a significant global health threat, with severe complications observed in vulnerable …
Safety and immunogenicity of a live-attenuated chikungunya virus vaccine in endemic areas of Brazil: interim results of a double-blind, randomised, placebo …
V Buerger, S Hadl, M Schneider, M Schaden… - The Lancet Infectious …, 2024 - thelancet.com
Background Chikungunya outbreaks have been reported in Brazil since 2014. Adolescents
are a sensitive population who would benefit from a prophylactic vaccine. This study …
are a sensitive population who would benefit from a prophylactic vaccine. This study …
A randomized, double-blinded Phase 3 study to demonstrate lot-to-lot consistency and to confirm immunogenicity and safety of the live-attenuated chikungunya virus …
R McMahon, U Fuchs, M Schneider… - Journal of Travel …, 2024 - academic.oup.com
Background The global spread of the chikungunya virus (CHIKV) increases the exposure
risk for individuals travelling to or living in endemic areas. This Phase 3 study was designed …
risk for individuals travelling to or living in endemic areas. This Phase 3 study was designed …
[HTML][HTML] Long chikungunya? An overview to immunopathology of persistent arthralgia
JEP Silveira-Freitas, ML Campagnolo… - World Journal of …, 2024 - ncbi.nlm.nih.gov
Chikungunya fever (CF) is caused by an arbovirus whose manifestations are extremely
diverse, and it has evolved with significant severity in recent years. The clinical signs …
diverse, and it has evolved with significant severity in recent years. The clinical signs …
[HTML][HTML] Enhanced attenuation of chikungunya vaccines expressing antiviral cytokines
C Chuong, C Cereghino, P Rai, TA Bates, M Oberer… - npj Vaccines, 2024 - nature.com
Alphaviruses are vector-borne, medically relevant, positive-stranded RNA viruses that cause
disease in animals and humans worldwide. Of this group, chikungunya virus (CHIKV) is the …
disease in animals and humans worldwide. Of this group, chikungunya virus (CHIKV) is the …
Capsid protein mediated evasion of IRAK1-dependent signalling is essential to Sindbis virus neuroinvasion and virulence in mice
Alphaviruses are arthropod-borne, single-stranded positive-sense RNA viruses that are
recognized as rapidly emerging pathogens. Despite being exquisitely sensitive to the effects …
recognized as rapidly emerging pathogens. Despite being exquisitely sensitive to the effects …
[HTML][HTML] Chikungunya and Mayaro Viruses Induce Chronic Skeletal Muscle Atrophy Triggered by Pro-Inflammatory and Oxidative Response
MOL da Silva, CM Figueiredo, RLS Neris… - International Journal of …, 2024 - mdpi.com
Chikungunya (CHIKV) and Mayaro (MAYV) viruses are arthritogenic alphaviruses that
promote an incapacitating and long-lasting inflammatory muscle–articular disease. Despite …
promote an incapacitating and long-lasting inflammatory muscle–articular disease. Despite …
[HTML][HTML] Antiviral and Virucidal Activities of Uncaria tomentosa (Cat's Claw) against the Chikungunya Virus
RC de Lima, LMM Valente, D Familiar Macedo… - Viruses, 2024 - mdpi.com
Uncaria tomentosa (UT) is a medicinal plant popularly known as cat's claw belonging to the
Rubiaceae family that has been reported to display antiviral and anti-inflammatory activities …
Rubiaceae family that has been reported to display antiviral and anti-inflammatory activities …
Analysis of spatial and demographic factors associated with chikungunya in Espírito Santo state, Brazil
MVS Clipes, CR Vicente… - Transactions of The …, 2024 - academic.oup.com
Background Chikungunya (CHIK) emerged in Brazil in 2014 and since then several
epidemics have been observed. This study aims to describe the spatial, social and …
epidemics have been observed. This study aims to describe the spatial, social and …