Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine

MR Hennessy, SM Creed, AM Gutridge, ES Rhoda… - 2024 - chemrxiv.org
Akuammicine (1), an indole alkaloid isolated from the seeds of Picralima nitida, is a selective
agonist of the kappa opioid receptor (κOR). To establish structure-activity relationships …

Heterocyclic compounds and imaging agents for imaging huntingtin protein

L Liu, M Lee, C Dominguez, PD Johnson… - US Patent …, 2024 - Google Patents
2024-01-04 Assigned to EVOTEC (UK) LTD. reassignment EVOTEC (UK) LTD.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …