Towards a general-purpose foundation model for computational pathology
Quantitative evaluation of tissue images is crucial for computational pathology (CPath) tasks,
requiring the objective characterization of histopathological entities from whole-slide images …
requiring the objective characterization of histopathological entities from whole-slide images …
Recent advances and evolving concepts in Still's disease
P Ruscitti, L Cantarini, PA Nigrovic… - Nature Reviews …, 2024 - nature.com
Still's disease is a rare inflammatory syndrome that encompasses systemic juvenile
idiopathic arthritis and adult-onset Still's disease, both of which can exhibit life-threatening …
idiopathic arthritis and adult-onset Still's disease, both of which can exhibit life-threatening …
A compendium of genetic regulatory effects across pig tissues
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …
established to develop a public resource of genetic regulatory variants in livestock, which is …
Smoking changes adaptive immunity with persistent effects
Individuals differ widely in their immune responses, with age, sex and genetic factors having
major roles in this inherent variability,,,,–. However, the variables that drive such differences …
major roles in this inherent variability,,,,–. However, the variables that drive such differences …
Nucleosides are overlooked fuels in central carbon metabolism
A Strefeler, J Blanco-Fernandez, AA Jourdain - Trends in Endocrinology & …, 2024 - cell.com
From our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and
circulate throughout the body and tissues. Nucleosides and nucleotides are classically …
circulate throughout the body and tissues. Nucleosides and nucleotides are classically …
Bayesian estimation of gene constraint from an evolutionary model with gene features
Measures of selective constraint on genes have been used for many applications, including
clinical interpretation of rare coding variants, disease gene discovery and studies of genome …
clinical interpretation of rare coding variants, disease gene discovery and studies of genome …
[HTML][HTML] Understanding the genetic complexity of puberty timing across the allele frequency spectrum
Pubertal timing varies considerably and is associated with later health outcomes. We
performed multi-ancestry genetic analyses on~ 800,000 women, identifying 1,080 signals for …
performed multi-ancestry genetic analyses on~ 800,000 women, identifying 1,080 signals for …
Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types
Uterine fibroids (UF), that can disrupt normal uterine function and cause significant physical
and psychological health problems, are observed in nearly 70% of women of reproductive …
and psychological health problems, are observed in nearly 70% of women of reproductive …
Translation variation across genetic backgrounds reveals a post-transcriptional buffering signature in yeast
EM Teyssonniere, Y Shichino, M Mito… - Nucleic Acids …, 2024 - academic.oup.com
Gene expression is known to vary among individuals, and this variability can impact the
phenotypic diversity observed in natural populations. While the transcriptome and proteome …
phenotypic diversity observed in natural populations. While the transcriptome and proteome …
Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets
Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-
specific epigenomic annotations and 3D genome information we generated and validated …
specific epigenomic annotations and 3D genome information we generated and validated …