T-cell help in the germinal center: homing in on the role of IL-21
L Petersone, LSK Walker - International Immunology, 2024 - academic.oup.com
Abstract Interleukin 21 (IL-21) is a pleiotropic cytokine that is overproduced in multiple
autoimmune settings. Provision of IL-21 from follicular helper T cells is an important …
autoimmune settings. Provision of IL-21 from follicular helper T cells is an important …
Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow
M Ferreira-Gomes, Y Chen, P Durek… - Nature …, 2024 - nature.com
Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently
releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different …
releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different …
The role of Interleukin-21 in autoimmune Diseases: Mechanisms, therapeutic Implications, and future directions
AM Shbeer, IA Robadi - Cytokine, 2024 - Elsevier
IL-21 is a multifunctional cytokine that regulates the functional activity of various immune
cells. Initial studies have shown that IL-21 can influence the differentiation, proliferation and …
cells. Initial studies have shown that IL-21 can influence the differentiation, proliferation and …
Human Immunodeficiencies Caused by Inborn Errors of B-Cell Development or Function
Mature B cells develop from hematopoietic stem cells in the bone marrow. Once generated,
B cells serve multiple roles in immune regulation and host defence. However, their most …
B cells serve multiple roles in immune regulation and host defence. However, their most …
B Cell Receptor Transgenic Mice as Tools to Study Memory B Cells
I Quast - Memory B-Cells: Methods and Protocols, 2024 - Springer
B cell receptor (BCR) transgenic mice allow the control of the initial target (antigen)
specificity of naïve B cells and to investigate their properties following activation. Here, I …
specificity of naïve B cells and to investigate their properties following activation. Here, I …
IL-21 Shapes the B Cell Response in a Context-Dependent Manner
Y Kim, F Manara, S Grassmann, K Belcheva, K Reyes… - bioRxiv, 2024 - biorxiv.org
The cytokine interleukin-21 (IL-21) is a pivotal T cell-derived signal crucial for germinal
center (GC) responses, but the precise mechanisms by which IL-21 influences B cell …
center (GC) responses, but the precise mechanisms by which IL-21 influences B cell …