Abstract Characterization and integration of the genome, epigenome, transcriptome,
proteome and metabolome of different datasets is difficult owing to a lack of ground truth …

Parkinson's disease (PD) is intricately linked to abnormal gut microbiota, yet the specific
microbiota influencing clinical outcomes remain poorly understood. Our study identified a …

Polyploidy (genome duplication) is a pivotal force in evolution. However, the interactions
between parental genomes in a polyploid nucleus, frequently involving subgenome …

DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and
transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes …

Cell fate transition involves dynamic changes of gene regulatory network and chromatin
landscape, requiring multiple levels of regulation, yet the cross-talk between …

Terrestrial enhanced weathering (EW) of silicate rocks, such as crushed basalt, on
farmlands is a promising scalable atmospheric carbon dioxide removal (CDR) strategy that …

Functional studies of long noncoding RNAs (lncRNAs) have been hindered by the lack of
methods to assess their evolution. Here we present lncRNA Homology Explorer (lncHOME) …

Abnormal activation of the intestinal mucosal immune system, resulting from damage to the
intestinal mucosal barrier and extensive invasion by pathogens, contributes to the …

Key innovations are fundamental to biological diversification, but their genetic basis is poorly
understood. A recent transition from egg-laying to live-bearing in marine snails (Littorina …

Key message Integrated QTL mapping and WGCNA condense the potential gene regulatory
network involved in oil accumulation. A glycosyl hydrolases gene (GhHSD1) for oil …