Advances in prostate cancer biomarkers and probes

K Li, Q Wang, X Tang, OU Akakuru, R Li… - Cyborg and Bionic …, 2024 - spj.science.org
Prostate cancer is one of the most prevalent malignant tumors in men worldwide, and early
diagnosis is essential to improve patient survival. This review provides a comprehensive …

Integrative analysis of ultra-deep RNA-seq reveals alternative promoter usage as a mechanism of activating oncogenic programmes during prostate cancer …

M Zhang, M Sjöström, X Cui, A Foye, K Farh… - Nature Cell …, 2024 - nature.com
Transcription factor (TF) proteins regulate gene activity by binding to regulatory regions,
most importantly at gene promoters. Many genes have alternative promoters (APs) bound by …

[HTML][HTML] Liquid Biomarkers in Prostate Cancer Diagnosis: Current Status and Emerging Prospects

Y Liu, K Hatano, N Nonomura - The World Journal of Men's Health, 2024 - wjmh.org
Prostate cancer (PCa) is a major health concern that necessitates appropriate diagnostic
approaches for timely intervention. This review critically evaluates the role of liquid biopsy …

Single cell-transcriptomic analysis informs the lncRNA landscape in metastatic castration resistant prostate cancer

D Saha, HX Dang, M Zhang, DA Quigley… - NPJ Genomic …, 2024 - nature.com
Metastatic castration-resistant prostate cancer (mCRPC) is a lethal form of prostate cancer.
Although long-noncoding RNAs (lncRNAs) have been implicated in mCRPC, past studies …

Knockdown of lncRNA SNHG20 suppressed the proliferation of cholangiocarcinoma by sponging miR-520f-3p

C Guan, Y Zhao, W Wang, Z Hu, L Liu… - Cancer Biotherapy & …, 2024 - liebertpub.com
Objective: A large number of studies had found that small nucleolar RNA host gene 20
(SNHG20) was a long noncoding RNA (lncRNA) that played important regulatory functions …

Identification of Selection Signatures and Candidate Genes Related to Environmental Adaptation and Economic Traits in Tibetan Pigs

P Liu, Y Liang, L Li, X Lv, Z He, Y Gu - Animals, 2024 - mdpi.com
Simple Summary Modern agricultural methods have led to the introduction of normally
highland Tibetan pigs to lowland areas because of their high-quality meat. Similar to …

Long non-coding RNA NRAV in the 12q24.31 risk locus drives gastric cancer development through glucose metabolism reprogramming

Y Zhang, Y Gao, F Li, Q Qi, Q Li, Y Gu, Z Zheng… - …, 2024 - academic.oup.com
Long non-coding RNAs (lncRNAs) serve as vital candidates to mediate cancer risk. Here,
we aimed to identify the risk single-nucleotide polymorphisms (SNPs)-induced lncRNAs and …

Integrated enhancer regulatory network by enhancer–promoter looping in gastric cancer

T Zhu, A Okabe, G Usui, R Fujiki, D Komiyama… - NAR …, 2024 - academic.oup.com
Enhancer cis-regulatory elements play critical roles in gene regulation at many stages of cell
growth. Enhancers in cancer cells also regulate the transcription of oncogenes. In this study …

Activation of the YY1-UGT2B7 axis promotes mammary estrogen homeostasis dysregulation and exacerbates breast tumor metastasis

J Xu, Y Zhou, S He, Y Wang, J Ma, C Li, Z Liu… - Drug Metabolism and …, 2024 - ASPET
Metastasis is the most common pathway of cancer death. The lack of effective predictors of
breast cancer metastasis is a pressing issue in clinical practice. Therefore, exploring the …

Identification of lncRNA PCAT19 as potential novel biomarker for colorectal cancer

A Masoud, P Mohamadynejad - Gene, 2024 - Elsevier
Long non-coding RNAs have been implicated in biological processes, and are dysregulated
in types of cancer. Studies have shown that PCAT19 and CKMT2-AS1 lncRNAs promote …