[HTML][HTML] Multiple Functions of Hepatitis E Virus ORF3

F Jiao, Y Zhao, G Zhou, C Meng, L Wang, S Wu, J Li… - Microorganisms, 2024 - mdpi.com
Hepatitis E (Hepatitis E, HE) is an acute and chronic infectious hepatitis caused by hepatitis
E virus (Hepatitis E Virus, HEV) infection, which is responsible for most acute hepatitis in the …

Hepatitis E virus ORF3 protein hijacking thioredoxin domain-containing protein 5 (TXNDC5) for its stability to promote viral particle release

Y Sheng, Y Deng, X Li, P Ji, X Sun, B Liu, J Zhu… - Journal of …, 2024 - Am Soc Microbiol
Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide,
responsible for approximately 20 million infections annually. Among the three open reading …

[HTML][HTML] Pathogenesis and clinical features of severe hepatitis E virus infection

L Orosz, KP Sárvári, Á Dernovics… - World Journal of …, 2024 - ncbi.nlm.nih.gov
The hepatitis E virus (HEV), a member of the Hepeviridae family, is a small, non-enveloped
icosahedral virus divided into eight distinct genotypes (HEV-1 to HEV-8). Only genotypes 1 …

Targeting cellular cathepsins inhibits hepatitis E virus entry

M Klöhn, T Burkard, J Janzen, JA Haase, A Gömer… - Hepatology, 2024 - journals.lww.com
Conclusions: In summary, our study highlights the pivotal role of lysosomal cathepsins,
especially CTSL, in the HEV entry process. The profound anti-HEV efficacy of the pan …

Label-Free Quantitative Analysis of Pig Liver Proteome after Hepatitis E Virus Infection

C Martino, A Di Luca, F Bennato, A Ianni, F Passamonti… - Viruses, 2024 - mdpi.com
Hepatitis E represents an emerging zoonotic disease caused by the Hepatitis E virus (HEV),
for which the main route of transmission is foodborne. In particular, infection in humans has …

Processing of the Hepatitis E virus ORF1 nonstructural polyprotein

YA Karpe - Frontiers in Virology, 2024 - frontiersin.org
Hepatitis E viruses (HEV) Open Reading Frame 1 (ORF1) encodes a non-structural
polyprotein. In most positive-sense RNA viruses found in animals, this non-structural …