Parthanatos is a cell death signaling pathway that has emerged as a compelling target for
pharmaceutical intervention. It plays a pivotal role in the neuron loss and neuroinflammation …

Thrombosis, a coagulation disorder, occurs due to altered levels of coagulation, fibrinolytic
and immune factors, which are otherwise known to maintain hemostasis in normal …

Excessive amounts of reactive oxygen species (ROS) lead to macromolecular damage and
high levels of cell death with consequent pathological sequelae. We hypothesized that …

Abstract Poly (ADP-ribosylation)(PARylation) is a post-translational modification mediated
by a subset of ADP-ribosyl transferases (ARTs). Although PARylation-inhibition based …

Summary Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) not only suppress
PARP1 catalytic activity but also prolong its association to damaged chromatin. Here …

Sepsis is a dysregulated response to infection that can result in life-threatening organ
failure, and septic cardiomyopathy is a serious complication involving ferroptosis. Olaparib …

Background Type 2 diabetes mellitus (T2DM) is characterized by disrupted glucose
homeostasis and metabolic abnormalities, with oxidative stress and inflammation playing …

Abstract PARP-1 (Poly (ADP-ribose) polymerase 1) is a nuclear enzyme and plays a key
role in many cellular functions, such as DNA repair, modulation of chromatin structure, and …

PARP2, that belongs to the family of ADP-ribosyl transferase enzymes (ART), is a discovery
of the millennium, as it was identified in 1999. Although PARP2 was described initially as a …

Bleomycin-induced lung pathology in rodents is a well recognized animal model widely
used for evaluation of new therapeutic approaches in treatment of lung inflammation and …