Proteogenomics refers to the integration of comprehensive genomic, transcriptomic, and
proteomic measurements from the same samples with the goal of fully understanding the …

Clear cell renal cell carcinoma (ccRCC) is a complex disease with remarkable immune and
metabolic heterogeneity. Here we perform genomic, transcriptomic, proteomic, metabolomic …

Technological advances in mass spectrometry and proteomics have made it possible to
perform larger-scale and more-complex experiments. The volume and complexity of the …

We present a framework for the analysis of multiplexed mass spectrometry proteomics data
that reduces estimation error when combining multiple isobaric batches. Variations in the …

The evolutionary trajectory of glioblastoma (GBM) is a multifaceted biological process that
extends beyond genetic alterations alone. Here, we perform an integrative proteogenomic …

Background Molecular understanding of muscle-invasive (MIBC) and non–muscle-invasive
(NMIBC) bladder cancer is currently based primarily on transcriptomic and genomic …

Adjuvant chemotherapy benefits patients with resected pancreatic ductal adenocarcinoma
(PDAC), but the compromised physical state of post-operative patients can hinder …

Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-
specific epigenomic annotations and 3D genome information we generated and validated …

Cetuximab therapy is the major treatment for colorectal cancer (CRC), but drug resistance
limits its effectiveness. Here, we perform longitudinal and deep proteomic profiling of 641 …

Novel perioperative strategies are needed to reduce recurrence rates in patients undergoing
nephrectomy for high-risk, non-metastatic clear cell renal cell carcinoma (ccRCC). We …