[HTML][HTML] Endothelial Protein C Receptor and Its Impact on Rheumatic Disease

ZD O'Hehir, T Lynch, S O'Neill, L March… - Journal of Clinical …, 2024 - mdpi.com
Endothelial Protein C Receptor (EPCR) is a key regulator of the activated protein C anti-
coagulation pathway due to its role in the binding and activation of this protein. EPCR also …

Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model

M Xue, CJ Jackson, H Lin, R Zhao, HPH Liang… - International Journal of …, 2024 - mdpi.com
Endothelial protein C receptor (EPCR) is a receptor for the natural anti-coagulant activated
protein C (aPC). It mediates the anti-inflammatory and barrier-protective functions of aPC …

Decreased expression of TIGIT on CD14+ monocytes correlates with clinical features and laboratory parameters of patients with primary Sjögren's syndrome

P Zhao, C Peng, X Chang, W Cheng, Y Yang… - Clinical …, 2024 - Springer
Objectives The purpose of this study was to investigate the expression of T-cell
immunoglobulin and ITIM domain (TIGIT) in peripheral circulation of primary Sjögren's …

EPCR deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells

M Xue, H Lin, HPH Liang, L Bereza-Malcolm… - …, 2024 - academic.oup.com
Objectives Endothelial protein C receptor (EPCR) is highly expressed in synovial tissues of
patients with RA, but the function of this receptor remains unknown in RA. This study …

TIGIT 与相关皮肤疾病的研究进展

王万丝, 沈嘉庆, 刘毅 - 中国麻风皮肤病杂志, 2024 - zgmfskin.com
共抑制受体TIGIT 由免疫球蛋白和免疫受体酪氨酸抑制基序组成ꎬ 主要表达在活化的T
细胞和先天免疫淋巴细胞表面ꎮ TIGIT 在黑素瘤, 皮肤T 细胞淋巴瘤等皮肤肿瘤中表达上调ꎬ …