Immunotherapy has emerged as a promising new treatment modality for head and neck
cancer, offering the potential for targeted and effective cancer management. Squamous cell …

Cell–cell communication is essential to many key biological processes. Intercellular
communication is generally mediated by ligand–receptor interactions (LRIs). Thus, building …

The tumor microenvironment (TME) is a complex system composed mainly of tumor cells,
mesenchymal cells and immune cells. Macrophages, also known as tumor‑associated …

Macrophages are immune cells in the TME that can not only inhibit angiogenesis,
extracellular matrix remodeling, cancer cell proliferation, and metastasis but also mediate …

Simple Summary Once in an immunosuppressive tumoral microenvironment (TME),
macrophages take over an essential role by activating signaling pathways such as STAT3 …

Background The prevalence of HPV‐negative oropharyngeal cancer (OPC) is higher in
Asian countries. Patients with HPV‐negative OPC suffer poor outcomes. Multi‐omics …

Head and neck cancer (HNC) is a challenging disease that lacks effective treatment,
particularly in the cases that spread locoregionally and metastasize distantly, dramatically …

Purpose: Recently, CD24 on tumor cells was identified as a phagocytic inhibitor contributing
to an immunosuppressive tumor microenvironment via binding to Siglec-10 on …

We aimed to identify an effective metabolic subtype and risk score to predict survival and
immunotherapy response in head and neck squamous cell carcinoma (HNSCC). Data were …

Adult IDH-wildtype glioblastoma (GBM) is a highly aggressive brain tumor with no
established immunotherapy or targeted therapy. Recently, CD32+ HLA-DR hi macrophages …