RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …

Tumours can arise from thyroid follicular cells if they acquire driver mutations that
constitutively activate the MAPK signalling pathway. In addition, a limited set of additional …

Over half of hepatocellular carcinoma (HCC) cases diagnosed worldwide are in China,–.
However, whole-genome analysis of hepatitis B virus (HBV)-associated HCC in Chinese …

A growing body of evidence indicates an important role of miRNAs in cancer; however, there
is no definitive, convenient-to-use list of cancer-related miRNAs or miRNA genes that may …

Around 75% of breast cancer (BC) patients have tumors expressing the predictive biomarker
estrogen receptor α (ER) and are offered endocrine therapy. One-third eventually develop …

Genetic changes in repetitive sequences are a hallmark of cancer and other diseases, but
characterizing these has been challenging using standard sequencing approaches. We …

The advent of perturbation-based massively parallel reporter assays (MPRAs) technique
has facilitated the delineation of the roles of non-coding regulatory elements in orchestrating …

The landscape of non-coding mutations in cancer progression and immune evasion is
largely unexplored. Here, we identify transcrptome-wide somatic and germline 3 …

In the past two decades, technological advances have brought unprecedented insights into
the paediatric cancer genome revealing characteristics distinct from those of adult cancer …

This study introduces an innovative detection system for multiple cancer biomarkers,
employing transcription isothermal amplification methods in conjunction with a tetrahedral …