Normothermic machine perfusion systems: where do we go from here?
S López-Martínez, C Simón, X Santamaria - Transplantation, 2024 - journals.lww.com
Normothermic machine perfusion (NMP) aims to preserve organs ex vivo by simulating
physiological conditions such as body temperature. Recent advancements in NMP system …
physiological conditions such as body temperature. Recent advancements in NMP system …
Focusing on ischemic reperfusion injury in the new era of dynamic machine perfusion in liver transplantation
G Chullo, A Panisello-Rosello, N Marquez… - International Journal of …, 2024 - mdpi.com
Liver transplantation is the most effective treatment for end-stage liver disease. Transplant
indications have been progressively increasing, with a huge discrepancy between the …
indications have been progressively increasing, with a huge discrepancy between the …
Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes
L Große-Segerath, P Follert, K Behnke, J Ettich… - Nature …, 2024 - nature.com
Recently, we have shown that after partial hepatectomy (PHx), an increased hepatic blood
flow initiates liver growth in mice by vasodilation and mechanically-triggered release of …
flow initiates liver growth in mice by vasodilation and mechanically-triggered release of …
Discarded livers tested by normothermic machine perfusion in the VITTAL trial: secondary end points and 5-year outcomes
H Mergental, RW Laing, AJ Kirkham, G Clarke… - Liver …, 2024 - journals.lww.com
Normothermic machine perfusion (NMP) enables pretransplant assessment of high-risk
donor livers. The VITTAL trial demonstrated that 71% of the currently discarded organs could …
donor livers. The VITTAL trial demonstrated that 71% of the currently discarded organs could …
US liver transplant outcomes after normothermic regional perfusion vs standard super rapid recovery
AL Brubaker, MT Sellers, PL Abt, KP Croome… - JAMA …, 2024 - jamanetwork.com
Importance Normothermic regional perfusion (NRP) is an emerging recovery modality for
transplantable allografts from controlled donation after circulatory death (cDCD) donors. In …
transplantable allografts from controlled donation after circulatory death (cDCD) donors. In …
Liver transplantation with uncontrolled versus controlled DCD donors using normothermic regional perfusion and ex-situ machine perfusion
D Ghinolfi, D Patrono, R De Carlis… - Liver …, 2024 - journals.lww.com
In Italy, 20 minutes of continuous, flat-line electrocardiogram are required for death
declaration, which significantly increases the risks of donation after circulatory death (DCD) …
declaration, which significantly increases the risks of donation after circulatory death (DCD) …
Liver machine perfusion technology: Expanding the donor pool to improve access to liver transplantation
S Canizares, A Montalvan… - American Journal of …, 2024 - Elsevier
The imbalance between organ supply and demand continues to limit the broader benefits of
organ transplantation. Machine perfusion (MP) may increase the supply of donor livers by …
organ transplantation. Machine perfusion (MP) may increase the supply of donor livers by …
A cell-free nutrient-supplemented perfusate allows four-day ex vivo metabolic preservation of human kidneys
MJA de Haan, ME Jacobs, FMR Witjas… - Nature …, 2024 - nature.com
The growing disparity between the demand for transplants and the available donor supply,
coupled with an aging donor population and increasing prevalence of chronic diseases …
coupled with an aging donor population and increasing prevalence of chronic diseases …
Strategies to improve the utilization and function of DCD livers
SC Kim, DP Foley - Transplantation, 2024 - journals.lww.com
Despite the increased usage of livers from donation after circulatory death (DCD) donors in
the last decade, many patients remaining on the waitlist who need a liver transplant. Recent …
the last decade, many patients remaining on the waitlist who need a liver transplant. Recent …
Impact of Back-to-Base Normothermic Machine Perfusion on Complications and Costs: A Multi-Center, Real-World Risk-Matched Analysis
Objective: Assess cost and complication outcomes after liver transplantation (LT) using
normothermic machine perfusion (NMP) Summary Background Data: End-ischemic NMP is …
normothermic machine perfusion (NMP) Summary Background Data: End-ischemic NMP is …