Normothermic machine perfusion systems: where do we go from here?

S López-Martínez, C Simón, X Santamaria - Transplantation, 2024 - journals.lww.com
Normothermic machine perfusion (NMP) aims to preserve organs ex vivo by simulating
physiological conditions such as body temperature. Recent advancements in NMP system …

Focusing on ischemic reperfusion injury in the new era of dynamic machine perfusion in liver transplantation

G Chullo, A Panisello-Rosello, N Marquez… - International Journal of …, 2024 - mdpi.com
Liver transplantation is the most effective treatment for end-stage liver disease. Transplant
indications have been progressively increasing, with a huge discrepancy between the …

Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes

L Große-Segerath, P Follert, K Behnke, J Ettich… - Nature …, 2024 - nature.com
Recently, we have shown that after partial hepatectomy (PHx), an increased hepatic blood
flow initiates liver growth in mice by vasodilation and mechanically-triggered release of …

Discarded livers tested by normothermic machine perfusion in the VITTAL trial: secondary end points and 5-year outcomes

H Mergental, RW Laing, AJ Kirkham, G Clarke… - Liver …, 2024 - journals.lww.com
Normothermic machine perfusion (NMP) enables pretransplant assessment of high-risk
donor livers. The VITTAL trial demonstrated that 71% of the currently discarded organs could …

US liver transplant outcomes after normothermic regional perfusion vs standard super rapid recovery

AL Brubaker, MT Sellers, PL Abt, KP Croome… - JAMA …, 2024 - jamanetwork.com
Importance Normothermic regional perfusion (NRP) is an emerging recovery modality for
transplantable allografts from controlled donation after circulatory death (cDCD) donors. In …

Liver transplantation with uncontrolled versus controlled DCD donors using normothermic regional perfusion and ex-situ machine perfusion

D Ghinolfi, D Patrono, R De Carlis… - Liver …, 2024 - journals.lww.com
In Italy, 20 minutes of continuous, flat-line electrocardiogram are required for death
declaration, which significantly increases the risks of donation after circulatory death (DCD) …

Liver machine perfusion technology: Expanding the donor pool to improve access to liver transplantation

S Canizares, A Montalvan… - American Journal of …, 2024 - Elsevier
The imbalance between organ supply and demand continues to limit the broader benefits of
organ transplantation. Machine perfusion (MP) may increase the supply of donor livers by …

A cell-free nutrient-supplemented perfusate allows four-day ex vivo metabolic preservation of human kidneys

MJA de Haan, ME Jacobs, FMR Witjas… - Nature …, 2024 - nature.com
The growing disparity between the demand for transplants and the available donor supply,
coupled with an aging donor population and increasing prevalence of chronic diseases …

Strategies to improve the utilization and function of DCD livers

SC Kim, DP Foley - Transplantation, 2024 - journals.lww.com
Despite the increased usage of livers from donation after circulatory death (DCD) donors in
the last decade, many patients remaining on the waitlist who need a liver transplant. Recent …

Impact of Back-to-Base Normothermic Machine Perfusion on Complications and Costs: A Multi-Center, Real-World Risk-Matched Analysis

CJ Wehrle, M Zhang, M Khalil, A Pita, JM Esfeh… - Annals of …, 2024 - journals.lww.com
Objective: Assess cost and complication outcomes after liver transplantation (LT) using
normothermic machine perfusion (NMP) Summary Background Data: End-ischemic NMP is …