Live Microscopy of Multicellular Spheroids with the Multimodal Near-Infrared Nanoparticles Reveals Differences in Oxygenation Gradients

AC Debruyne, IA Okkelman, N Heymans, C Pinheiro… - ACS …, 2024 - ACS Publications
Assessment of hypoxia, nutrients, metabolite gradients, and other hallmarks of the tumor
microenvironment within 3D multicellular spheroid and organoid models represents a …

Multimodal Mass Spectrometry Imaging of an Osteosarcoma Multicellular Tumour Spheroid Model to Investigate Drug-Induced Response

SM Pearce, NA Cross, DP Smith, MR Clench, LE Flint… - Metabolites, 2024 - mdpi.com
A multimodal mass spectrometry imaging (MSI) approach was used to investigate the
chemotherapy drug-induced response of a Multicellular Tumour Spheroid (MCTS) 3D cell …

[HTML][HTML] Reduction of N-Acetylglucosaminyltransferase-I Activity Promotes Neuroblastoma Invasiveness and EGF-Stimulated Proliferation In Vitro

AP Burch, MK Hall, D Wease, RA Schwalbe - International Journal of …, 2024 - mdpi.com
Aberrant N-glycosylation has been associated with progression of the pediatric cancer
neuroblastoma (NB) but remains understudied. Here we investigated oligomannose N …