Multicancer detection (MCD) tests use a single, easily obtainable biospecimen, such as
blood, to screen for more than one cancer concurrently. MCD tests can potentially be used to …

Asparagine, an important amino acid in mammals, is produced in several organs and is
widely used for the production of other nutrients such as glucose, proteins, lipids, and …

Background & Aims Colorectal cancer (CRC) screening is highly effective but underused.
Blood-based biomarkers (liquid biopsy) could improve screening participation. Methods …

Background & Aims To date, no regional evidence of long-term colorectal cancer (CRC) risk
reduction after endoscopic premalignant lesion removal has been established. We aimed to …

Background Colorectal cancer (CRC) incidence at ages< 50 years is increasing worldwide.
Screening initiation was lowered to 45 years in the United States. The cost‐effectiveness of …

Background Cancer screening trials have required large sample sizes and long time-
horizons to demonstrate cancer mortality reductions, the primary goal of cancer screening …

Background & Aims Mailed outreach for colorectal cancer (CRC) screening increases
uptake but it is unclear how to offer the choice of testing. We evaluated if the active choice …

Importance The fecal immunochemical test (FIT) is widely used for colorectal cancer (CRC)
screening, but evidence of its effectiveness is limited. Objective To evaluate whether FIT …

Importance Randomized clinical screening trials have shown that sigmoidoscopy screening
reduces colorectal cancer (CRC) incidence and mortality. Colonoscopy has largely replaced …

Colonoscopy-based screening provides protection against colorectal cancer (CRC), but the
optimal starting age and time intervals of screening colonoscopies are unknown. We aimed …