Kaempferol and atherosclerosis: From mechanism to medicine

M Chen, J Xiao, HR El-Seedi, KS Woźniak… - Critical Reviews in …, 2024 - Taylor & Francis
Natural products possess pleiotropic cardiovascular protective effects owing to their anti-
oxidation, anti-inflammation and anti-thrombotic properties. Kaempferol,(3, 5, 7-trihydroxy-2 …

Advances in Engineered Macrophages: A New Frontier in Cancer Immunotherapy

S Yang, Y Wang, J Jia, Y Fang, Y Yang, W Yuan… - Cell Death & …, 2024 - nature.com
Macrophages, as pivotal cells within the tumour microenvironment, significantly influence
the impact of and reactions to treatments for solid tumours. The rapid evolution of …

[HTML][HTML] M2 exosomes modified by hydrogen sulfide promoted bone regeneration by moesin mediated endocytosis

Y Zhou, C Han, Z Zhu, P Chen, Y Wang, S Lin, L Chen… - Bioactive Materials, 2024 - Elsevier
Bone defects caused by trauma or tumor led to high medical costs and poor life quality for
patients. The exosomes, micro vesicles of 30–150 nm in diameter, derived from …

[HTML][HTML] Unique macrophage phenotypes activated by BMP signaling in breast cancer bone metastases

CL Ihle, DM Straign, JA Canari, KC Torkko, KL Zolman… - JCI insight, 2024 - ncbi.nlm.nih.gov
Metastatic breast cancer (mBC) tissue in bone was systematically profiled to define the
composition of the tumor microenvironment. Gene expression identified a high myeloid …

Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery

G Zhao, L Xue, HC Geisler, J Xu, X Li… - Proceedings of the …, 2024 - National Acad Sciences
Macrophages are integral components of the innate immune system, playing a dual role in
host defense during infection and pathophysiological states. Macrophages contribute to …

Endometriosis and adenomyosis: similarities and differences

J Donnez, CA Stratopoulou, MM Dolmans - Best Practice & Research …, 2024 - Elsevier
Deep endometriosis and uterine adenomyosis are two frequently encountered conditions
affecting approximately 200 million women worldwide. They are closely related, showing …

Prediction of six macrophage phenotypes and their IL-10 content based on single-cell morphology using artificial intelligence

M Selig, L Poehlman, NC Lang, M Völker… - Frontiers in …, 2024 - frontiersin.org
Introduction The last decade has led to rapid developments and increased usage of
computational tools at the single-cell level. However, our knowledge remains limited in how …

[HTML][HTML] HSF1 Inhibits Antitumor Immune Activity in Breast Cancer by Suppressing CCL5 to Block CD8+ T-cell Recruitment

C Jacobs, S Shah, WC Lu, H Ray, J Wang… - Cancer Research, 2024 - AACR
Abstract Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that promotes
cancer cell malignancy. To provide a better understanding of the biological processes …

Effects of chemotherapy on the immune system: Implications for cancer treatment and patient outcomes

A Sharma, S Jasrotia, A Kumar - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Chemotherapy is a cornerstone of cancer treatment, but it can also induce immune
suppression, which can have significant implications for patient outcomes. This review paper …

The implications of FASN in immune cell biology and related diseases

Y Xiao, Y Yang, H Xiong, G Dong - Cell Death & Disease, 2024 - nature.com
Fatty acid metabolism, particularly fatty acid synthesis, is a very important cellular
physiological process in which nutrients are used for energy storage and biofilm synthesis …