COVID-19 and bone loss: a review of risk factors, mechanisms, and future directions

A Creecy, OD Awosanya, A Harris, X Qiao… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review SARS-CoV-2 drove the catastrophic global phenomenon of the
COVID-19 pandemic resulting in a multitude of systemic health issues, including bone loss …

SARS-CoV-2 and its multifaceted impact on bone health: mechanisms and clinical evidence

A Harris, A Creecy, OD Awosanya, T McCune… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review SARS-CoV-2 infection, the culprit of the COVID-19 pandemic,
has been associated with significant long-term effects on various organ systems, including …

Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis

MT Au, J Ni, K Tang, W Wang, L Zhang, H Wang… - Nature …, 2024 - nature.com
Joint pain and osteoarthritis can occur as coronavirus disease 2019 (COVID-19) sequelae
after infection. However, little is known about the damage to articular cartilage. Here we …

Mechanistic insights into bone remodelling dysregulation by human viral pathogens

CCS Caetano, T Azamor, NM Meyer… - Nature …, 2024 - nature.com
Bone-related diseases (osteopathologies) associated with human virus infections have
increased around the globe. Recent findings have highlighted the intricate interplay …

[HTML][HTML] NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway

R Yang, W Yu, L Lin, Z Cui, J Tang, G Li, M Jin… - Journal of Advanced …, 2024 - Elsevier
Introduction Excessive osteoclastogenesis is a key driver of inflammatory bone loss.
Suppressing osteoclastogenesis has always been considered essential for the treatment of …

Bone-organ axes: bidirectional crosstalk

AF Deng, FX Wang, SC Wang, YZ Zhang, L Bai… - Military Medical …, 2024 - Springer
In addition to its recognized role in providing structural support, bone plays a crucial role in
maintaining the functionality and balance of various organs by secreting specific cytokines …

Risks of incident major osteoporotic fractures following SARS-CoV-2 infection among older individuals: a population-based cohort study in Hong Kong

DTW Lui, X Xiong, CL Cheung, FTT Lai… - Journal of Bone and …, 2024 - academic.oup.com
Population-based epidemiological studies on post-acute phase coronavirus 2019 (COVID-
19)-related fractures in older adults are lacking. This study aims to examine the risk of …

Genome-scale CRISPR-Cas9 screen identifies host factors as potential therapeutic targets for SARS-CoV-2 infection

M Sakai, Y Masuda, Y Tarumoto, N Aihara, Y Tsunoda… - Iscience, 2024 - cell.com
Although many host factors important for severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection have been reported, the mechanisms by which the virus interacts …

The abortive SARS‐CoV‐2 infection of osteoclast precursors promotes their differentiation into osteoclasts

F Sviercz, P Jarmoluk, J Godoy Coto… - Journal of Medical …, 2024 - Wiley Online Library
Abstract The Coronavirus Disease 2019 (COVID‐19) pandemic has resulted in the loss of
millions of lives, although a majority of those infected have managed to survive …

[HTML][HTML] Advances in nanoscopic mechanobiological structure-property relationship in human bones for tailored fragility prevention

F Buccino, F Giuseppoli, T Kochetkova… - Materials Today …, 2024 - Elsevier
It is well documented that fragility fractures represent an enormous health, economic and
psycho-social burden, leading to severe pain, loss of mobility, and even death. While clinical …