The emerging neuroimmune hypothesis of bipolar disorder: an updated overview of neuroimmune and microglial findings

A Chaves‐Filho, C Eyres, L Blöbaum… - Journal of …, 2024 - Wiley Online Library
Bipolar disorder (BD) is a severe and multifactorial disease, with onset usually in young
adulthood, which follows a progressive course throughout life. Replicated epidemiological …

A Systematic Review of the Molecular and Cellular Alterations Induced by Cannabis that may serve as Risk Factors for Bipolar Disorder

A Delgado-Sequera, C Garcia-Mompo… - International Journal …, 2024 - academic.oup.com
Background Cannabis use is a risk factor of psychiatric illness, such as bipolar disorder type-
I (BDI). Indeed, cannabis use strongly influences the onset and clinical course of BDI …

Exploring functional dysconnectivity in schizophrenia: alterations in eigenvector centrality mapping and insights into related genes from transcriptional profiles

Y Ji, M Cai, Y Zhou, J Ma, Y Zhang, Z Zhang, J Zhao… - Schizophrenia, 2024 - nature.com
Schizophrenia is a mental health disorder characterized by functional dysconnectivity.
Eigenvector centrality mapping (ECM) has been employed to investigate alterations in …

PGS-Depot: a comprehensive resource for polygenic scores constructed by summary statistics based methods

C Cao, S Zhang, J Wang, M Tian, X Ji… - Nucleic Acids …, 2024 - academic.oup.com
Polygenic score (PGS) is an important tool for the genetic prediction of complex traits.
However, there are currently no resources providing comprehensive PGSs computed from …

Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence

A Ratanatharathorn, L Quan, KC Koenen… - Translational …, 2024 - nature.com
Research has suggested that mental illness may be a risk factor for, as well as a sequela of,
experiencing intimate partner violence (IPV). The association between IPV and mental …

Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we?

O Iakunchykova, EH Leonardsen, Y Wang - Translational Psychiatry, 2024 - nature.com
The question of whether immune dysfunction contributes to risk of psychiatric disorders has
long been a subject of interest. To assert this hypothesis a plethora of correlative evidence …

Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder

S Mirza, CNC Lima, D Favero-Campbell… - Translational …, 2024 - nature.com
Suicide attempt (SA) risk is elevated in individuals with bipolar disorder (BD), and DNA
methylation patterns may serve as possible biomarkers of SA. We conducted epigenome …

Characteristics of changes in plasma proteome profiling after sleeve gastrectomy

Y Zhang, C Shi, H Wu, H Yan, M Xia, H Jiao… - Frontiers in …, 2024 - frontiersin.org
Bariatric surgery (BS), recognized as the most effective intervention for morbid obesity and
associated metabolic comorbidities, encompasses both weight loss-dependent and weight …

Structural characterization of a polymorphic repeat at the CACNA1C schizophrenia locus

R Moya, X Wang, RW Tsien, MT Maurano - medRxiv, 2024 - medrxiv.org
Genetic variation within intron 3 of the CACNA1C calcium channel gene is associated with
schizophrenia and bipolar disorder, but analysis of the causal variants and their effect is …

Progress and Implications from Genetic Studies of Bipolar Disorder

L Kong, Y Chen, Y Shen, D Zhang, C Wei, J Lai… - Neuroscience Bulletin, 2024 - Springer
With the advancements in gene sequencing technologies, including genome-wide
association studies, polygenetic risk scores, and high-throughput sequencing, there has …