Podocyte injury can disrupt the glomerular filtration barrier (GFB), leading to
podocytopathies that emphasize podocytes as the glomerulus's key organizer. The …

Accumulating evidence indicates that inflammatory and immunologic processes play a
significant role in the development and progression of glomerular diseases. Podocytes, the …

Despite clinical use of immunosuppressive agents, the immunopathogenesis of minimal
change disease (MCD) and focal segmental glomerulosclerosis (FSGS) remains unclear …

The soluble urokinase plasminogen activator receptor (suPAR) has been implicated in a
wide range of pathological conditions including primary nephrotic syndromes and acute …

Beyond the direct benefit that a transplanted organ provides to an individual recipient, the
study of the transplant process has the potential to create a better understanding of the …

Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus, with high
mortality rates despite medical advancements. The complexity of its pathogenesis, including …

The glomerular filtration barrier, comprising the inner layer of capillary fenestrated
endothelial cells, outermost podocytes, and the glomerular basement membrane between …

Interleukins are a family of 40 bioactive peptides that act through cell surface receptors to
induce a variety of intracellular responses. While interleukins are most commonly associated …

Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney
function. In this study we show that near-complete knockout of the closely related insulin-like …

Membranous nephropathy (MN), an autoimmune disease, can manifest at any age and is
among the most common causes of nephrotic syndrome in adults. In 80% of cases, the …