Diabetes mellitus (DM) is a highly prevalent disease worldwide, estimated to affect 1 in
every 11 adults; among them, 90–95% of cases are type 2 diabetes mellitus. This is partly …

Leptin is a hormone that is secreted by adipocytes in proportion to adipose tissue size, and
that informs the brain about the energy status of the body. Leptin acts through its receptor …

Obesity is often associated with aging. However, the mechanism of age-related obesity is
unknown. The melanocortin-4 receptor (MC4R) mediates leptin-melanocortin anti-obesity …

Abstract Ten-eleven translocation (TET) 2 is an enzyme that catalyzes DNA demethylation to
regulate gene expression by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine …

Background Increased adiposity during pregnancy may be related to offspring risk for mental
health disorders, although the biological mechanisms are poorly understood. One promising …

Purpose Biallelic pathogenic leptin gene variants cause severe early-onset obesity usually
associated with low or undetectable circulating leptin levels. Recently, variants have been …

The early stages of life, especially the period from conception to two years, are crucial for
shaping metabolic health and the risk of obesity in adulthood. Adipose tissue (AT) plays a …

Background Metabolic abnormalities are closely tied to the development of ovarian cancer
(OC), yet the relationship between anthropometric indicators as risk indicators for metabolic …

Nearly 90 clinicians and researchers from around the world attended the first IMPROVE
2022 International Meeting on Pathway‐Related Obesity. Delegates attended in person or …

This 2 volume set comprises of the 4th edition of Volume 1 and the 5thth edition of Volume 2.
The fifth edition of Volume 1 of Handbook of Obesity written by global experts covers the …