Single-cell omics: experimental workflow, data analyses and applications
Cells are the fundamental units of biological systems and exhibit unique development
trajectories and molecular features. Our exploration of how the genomes orchestrate the …
trajectories and molecular features. Our exploration of how the genomes orchestrate the …
Expression profiling of cerebrospinal fluid identifies dysregulated antiviral mechanisms in multiple sclerosis
Despite the overwhelming evidence that multiple sclerosis is an autoimmune disease,
relatively little is known about the precise nature of the immune dysregulation underlying the …
relatively little is known about the precise nature of the immune dysregulation underlying the …
Investigating RNA splicing as a source of cellular diversity using a binomial mixture model
K Isaev, DA Knowles - Machine Learning in Computational …, 2024 - proceedings.mlr.press
Alternative splicing (AS) contributes significantly to RNA and protein variability yet its role in
defining cellular diversity is not fully understood. While Smart-seq2 offers enhanced …
defining cellular diversity is not fully understood. While Smart-seq2 offers enhanced …
Mining alternative splicing patterns in scRNA-seq data using scASfind
Single-cell RNA-seq (scRNA-seq) is widely used for transcriptome profiling, but most
analyses focus on gene-level events, with less attention devoted to alternative splicing …
analyses focus on gene-level events, with less attention devoted to alternative splicing …
Splicing-aware resolution of scRNA-Seq data
Single-cell RNA sequencing (scRNA-Seq) provides invaluable insights in cell biology.
Current scRNA-Seq analytic approaches do not distinguish between spliced and unspliced …
Current scRNA-Seq analytic approaches do not distinguish between spliced and unspliced …
BRACE: A novel Bayesian-based imputation approach for dimension reduction analysis of alternative splicing at single-cell resolution
S Wen - bioRxiv, 2024 - biorxiv.org
Bayesian approach is a powerful tool to solve challenging questions in life sciences. One
such area of life sciences in which Bayesian approach has seen an increased utility in the …
such area of life sciences in which Bayesian approach has seen an increased utility in the …
DifferentialRegulation: a Bayesian hierarchical approach to identify differentially regulated genes
Although transcriptomics data is typically used to analyze mature spliced mRNA, recent
attention has focused on jointly investigating spliced and unspliced (or precursor-) mRNA …
attention has focused on jointly investigating spliced and unspliced (or precursor-) mRNA …