Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease
P Pleskač, CA Fargeas, R Veselska, D Corbeil… - Cellular & Molecular …, 2024 - Springer
Abstract Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively
associated with highly curved and prominent membrane structures. It is widely recognized …
associated with highly curved and prominent membrane structures. It is widely recognized …
The Impact of Glycosylation on the Functional Activity of CD133 and the Accuracy of Its Immunodetection
A Gisina, K Yarygin, A Lupatov - Biology, 2024 - mdpi.com
The membrane glycoprotein CD133 (prominin-1) is widely regarded as the main molecular
marker of cancer stem cells, which are the most malignant cell subpopulation within the …
marker of cancer stem cells, which are the most malignant cell subpopulation within the …
Evaluating CD133 as a Radiotheranostic Target in Small-Cell Lung Cancer
SM Sarrett, C Rodriguez, S Delaney… - Molecular …, 2024 - ACS Publications
Despite decades of work, small-cell lung cancer (SCLC) remains a frustratingly recalcitrant
disease. Both diagnosis and treatment are challenges: low-dose computed tomography (the …
disease. Both diagnosis and treatment are challenges: low-dose computed tomography (the …
Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration
N Shigesada, N Shikada, M Shirai, M Toriyama… - Cellular and Molecular …, 2024 - Springer
Retinitis pigmentosa (RP) and macular dystrophy (MD) cause severe retinal dysfunction,
affecting 1 in 4000 people worldwide. This disease is currently assumed to be intractable …
affecting 1 in 4000 people worldwide. This disease is currently assumed to be intractable …
Prominin 1 is crucial for the early development of photoreceptor outer segments
S Yanardag, S Rhodes, T Saravanan, T Guan… - Scientific Reports, 2024 - nature.com
Abstract Prominin 1 (PROM1) is a pentaspan transmembrane glycoprotein localized on the
nascent photoreceptor discs. Mutations in PROM1 are linked to various retinal diseases. In …
nascent photoreceptor discs. Mutations in PROM1 are linked to various retinal diseases. In …
Aberrant stem cell and developmental programs in pediatric leukemia
RE Ling, JW Cross, A Roy - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Hematopoiesis is a finely orchestrated process, whereby hematopoietic stem cells give rise
to all mature blood cells. Crucially, they maintain the ability to self-renew and/or differentiate …
to all mature blood cells. Crucially, they maintain the ability to self-renew and/or differentiate …
[HTML][HTML] 肿瘤干细胞生物学特性及其干性维持机制的研究进展
张文静， 赵可旭， 张可越， 陈晓阳， 郝明炫， 杨昭 - 生物工程学报, 2024 - wswxtb.ijournals.cn
肿瘤是威胁人类健康和社会发展最为严重的疾病之一, 也是全球第二大常见疾病死因.
最新统计数据显示, 恶性肿瘤在发达国家已取代心血管疾病成为第一大疾病死因. 肿瘤的耐药 …
最新统计数据显示, 恶性肿瘤在发达国家已取代心血管疾病成为第一大疾病死因. 肿瘤的耐药 …
Deciphering the Impact of PROM1 Alternative Splicing on Human Photoreceptor Development and Maturation
M Lako, MM Molina, B Dorgau, E Flood, S Letteboer… - 2024 - researchsquare.com
Conclusions: Importantly, the use of retinal organoids provides a valuable platform to study
AS and unravel disease mechanisms in a more physiologically relevant context, opening …
AS and unravel disease mechanisms in a more physiologically relevant context, opening …
The Protective Role of Lipocalin-2 in Kidney Transplantation: Intricate Mechanisms of Renoprotection and Alloimmunity Modulation
AM Pfefferkorn - 2024 - refubium.fu-berlin.de
Kidney transplantation (KTx) stands as the sole curative treatment option for individuals
afflicted with end-stage renal disease, providing them a renewed opportunity for kidney …
afflicted with end-stage renal disease, providing them a renewed opportunity for kidney …