Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
Cell type-specific roles of APOE4 in Alzheimer disease
The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist
Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
Updates on mouse models of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disease in the United
States (US). Animal models, specifically mouse models have been developed to better …
States (US). Animal models, specifically mouse models have been developed to better …
[HTML][HTML] An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer's brains
The dominant risk factors for late-onset Alzheimer's disease (AD) are advanced age and the
APOE4 genetic variant. To examine how these factors alter neuroimmune function, we …
APOE4 genetic variant. To examine how these factors alter neuroimmune function, we …
Immune Activation in Alzheimer Disease
Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …
efficient curative treatment available, its medical, social, and economic burdens are …
Mechanisms of sex differences in Alzheimer's disease
C Lopez-Lee, ERS Torres, G Carling, L Gan - Neuron, 2024 - cell.com
Alzheimer's disease (AD) and the mechanisms underlying its etiology and progression are
complex and multifactorial. The higher AD risk in women may serve as a clue to better …
complex and multifactorial. The higher AD risk in women may serve as a clue to better …
Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy
D Toral-Rios, JM Long, JD Ulrich, J Yu… - Journal of Experimental …, 2024 - rupress.org
Alzheimer's disease (AD) is characterized by amyloid plaques and neurofibrillary tangles, in
addition to neuroinflammation and changes in brain lipid metabolism. 25 …
addition to neuroinflammation and changes in brain lipid metabolism. 25 …
The importance of complement-mediated immune signaling in Alzheimer's disease pathogenesis
AF Batista, KA Khan, MT Papavergi… - International Journal of …, 2024 - mdpi.com
As an essential component of our innate immune system, the complement system is
responsible for our defense against pathogens. The complement cascade has complex …
responsible for our defense against pathogens. The complement cascade has complex …