Acute lymphoblastic leukemia (ALL) is one of the most rapidly changing hematological
malignancies with advanced understanding of the genetic landscape, detection methods of …

Although the study of leukemogenesis has traditionally focused on protein-coding genes,
the role of enhancer dysregulation is becoming increasingly recognized. The advent of high …

Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL) is an aggressive B-ALL
malignancy associated with high rates of relapse and inferior survival rate. While targeted …

PURPOSE Patients with Down syndrome (DS) and B-ALL experience increased rates of
relapse, toxicity, and death. We report results for patients with DS B-ALL enrolled on …

Introduction: Acute lymphoblastic leukemia (ALL) is a prevalent childhood cancer with high
cure rate, but poses a significant medical challenge in adults and relapsed patients …

B-cell lymphoblastic leukemia is a hematologic neoplasm that poses a serious health
concern in childhood. Genetic aberrations, such as mutations in the genes IL-7, IL7R, JAK1 …

Cytokine receptor-like factor 2 (CRLF2) and interleukin-7 receptor α (IL-7Rα) form a receptor
for thymic stromal lymphopoietin (TSLP). A somatic mutation consisting of the substitution of …

Abstract Background Philadelphia chromosome (Ph)–like B‐acute lymphoblastic leukemia
(B‐ALL) is a clinically significant, high‐risk genetic subtype of B‐ALL cases. There are few …

Abstract Background BCR:: ABL1-like or Philadelphia chromosome-like (Ph-like) acute
lymphoblastic leukemia (ALL) was first reported in 2009. Ph-like ALL is characterized by …

Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults
with a poor prognosis with relapsed or refractory (R/R) B-cell lineage ALL (B-ALL). Anti …