Current status and future perspectives of FGF21 analogues in clinical trials

ZSW Chui, Q Shen, A Xu - Trends in Endocrinology & Metabolism, 2024 - cell.com
Recent advances in fibroblast growth factor 21 (FGF21) biology and pharmacology have led
to the development of several long-acting FGF21 analogues and antibody-based mimetics …

[HTML][HTML] Targeting systemic inflammation in metabolic disorders. A therapeutic candidate for the prevention of cardiovascular diseases?

E Domingo, P Marques, V Francisco, L Piqueras… - Pharmacological …, 2024 - Elsevier
Cardiovascular disease (CVD) remains the leading cause of death and disability worldwide.
While many factors can contribute to CVD, atherosclerosis is the cardinal underlying …

Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023

MF Burak, TL Stanley, EA Lawson, SL Campbell… - The American Journal of …, 2024 - Elsevier
The rapidly evolving field of immunometabolism explores how changes in local immune
environments may affect key metabolic and cellular processes, including that of adipose …

Dynamic changes of immunocyte subpopulations in thermogenic activation of adipose tissues

Y Ye, H Wang, W Chen, Z Chen, D Wu… - Frontiers in …, 2024 - frontiersin.org
Objectives The effects of cold exposure on whole-body metabolism in humans have gained
increasing attention. Brown or beige adipose tissues are crucial in cold-induced …

[HTML][HTML] Weight-loss maintenance is accompanied by interconnected alterations in circulating FGF21-adiponectin-leptin and bioactive sphingolipids

M Fiorenza, A Checa, RM Sandsdal, SBK Jensen… - Cell Reports …, 2024 - cell.com
Weight loss is often followed by weight regain. Characterizing endocrine alterations
accompanying weight reduction and regain may disentangle the complex biology of weight …

Functional effects and mechanisms of Phyllanthus emblica fruit and gallic acid on metabolic diseases: Experimental evidence and clinical perspectives

X Gou, Y Ding, Y Wu, Y Tao, Y Wang, Y Wang, J Liu… - Food Bioscience, 2024 - Elsevier
Metabolic diseases have become a global health problem. In recent years, increasing
attention has been paid to finding effective ways to prevent or improve metabolic diseases …

[HTML][HTML] Plasticity of Adipose Tissues: Interconversion among White, Brown, and Beige Fat and Its Role in Energy Homeostasis

Y Peng, L Zhao, M Li, Y Liu, Y Shi, J Zhang - Biomolecules, 2024 - mdpi.com
Obesity, characterized by the excessive accumulation of adipose tissue, has emerged as a
major public health concern worldwide. To develop effective strategies for treating obesity, it …

Liraglutide induced browning of visceral white adipose through regulation of miRNAs in high-fat-diet-induced obese mice

L Zhao, W Li, P Zhang, D Wang, L Yang, G Yuan - Endocrine, 2024 - Springer
Objective Obesity is characterized by excessive accumulation of white adipose tissue (WAT).
Conversely, brown adipose tissue is protective against obesity. We recently reported …

Immune cells in adipose tissue microenvironment under physiological and obese conditions

Y Jiang, F Gong - Endocrine, 2024 - Springer
Purpose This review will focus on the immune cells in adipose tissue microenvironment and
their regulatory roles in metabolic homeostasis of adipose tissue and even the whole body …

M6A modification and T cells in adipose tissue inflammation

X Yang, H Tang, X Sun, Q Gui - Cell Biochemistry and Function, 2024 - Wiley Online Library
Adipose tissue in the obese state can lead to low‐grade chronic inflammation while inducing
or exacerbating obesity‐related metabolic diseases and impairing overall health. T cells …