Targeted protein degradation (TPD) has revolutionized drug discovery by selectively
eliminating specific proteins within and outside the cellular context. Over the past two …

Introduction Bromodomain-containing protein 4 (BRD4), an important epigenetic reader, is
closely associated with the pathogenesis and development of many diseases, including …

Targeted protein degradation (TPD) is an emerging therapeutic paradigm aimed at
eliminating the disease-causing protein with aberrant expression. Herein, we report a new …

We focus on drug repurposing in the Ras signaling pathway, considering structural
similarities of protein–protein interfaces. The interfaces formed by physically interacting …

Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules that bind and recruit
an E3 ubiquitin ligase to a targeted protein of interest, often through the utilization of a small …

Neurodegenerative diseases (NDD) are characterized by the gradual deterioration of
neuronal function and integrity, resulting in an overall decline in brain function. The existing …

Prion diseases are rare, fatal, progressive neurodegenerative disorders that affect both
animal and human. Human prion diseases mainly present as Creutzfeldt-Jakob disease …

Abnormal activation of EGFR is often associated with various malignant tumors, making it an
important target for antitumor therapy. However, traditional targeted inhibitors have several …

Small-molecule drugs are effective and thus most widely used. However, their applications
are limited by their reliance on active high-affinity binding sites, restricting their target …

The chemical understanding of biological processes provides not only a deeper insight but
also a solution to abnormal biological functioning. Protein degradation, a natural biological …