Two new series of oxadiazole and pyrazoline derivatives were designed and synthesized as
promising EGFR-TK inhibitors. The in vitro antiproliferative activity was studied against three …

Pyrazoline derivatives exhibit potential application as sensitive and selective chemosensors
for the recognition of Fe3+ ions. Their distinctive structure has both donating and accepting …

Pyrazolines are preferred to be stable heterocycles in medication development. It has been
established from previous research that the 2‐pyrazolone scaffold is a common pattern that …

Background Multidrug resistance in various cancer types is a major obstacle in cancer
treatment. The concept of a single drug molecular target often causes treatment failure due …

Brønsted ionic liquids (BILs) were designed and applied to catalyze intramolecular
cyclization of ketazines to 2-pyrazoline derivatives. Under the optimal conditions as 90° C …

Background: Pyrazoline is a heterocyclic compound with five members, two nitrogen atoms
in a circle, and one endocyclic bond. Pyrazoline is a popular electron-rich nitrogen carrier …

Protein tyrosine kinases play a role in the cell signaling pathways involving cell growth,
differentiation, apoptosis, and metabolism of cancer cells. Because of that, the molecular …

In last decade, many researchers have been developed potent heterocyclic compounds.
Pyrazolines are significant pharmacophore due to its medicinal applications such as …