Multifunctional nanoparticle-mediated combining therapy for human diseases
X Li, X Peng, M Zoulikha, GF Boafo, KT Magar… - … and Targeted Therapy, 2024 - nature.com
Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …
disease prevention and treatment. In preclinical investigations, combined effect of certain …
Histological disease activity as predictor of clinical relapse, hospitalization, and surgery in inflammatory bowel disease: systematic review and meta-analysis
M Shehab, S Al Akram, A Hassan… - Inflammatory Bowel …, 2024 - academic.oup.com
Background The clinical impact of histological remission on short-and long-term clinical
outcomes in patients with inflammatory bowel disease (IBD) is not well established. We …
outcomes in patients with inflammatory bowel disease (IBD) is not well established. We …
Composite assessment using intestinal ultrasound and calprotectin is accurate in predicting histological activity in ulcerative colitis: a cohort study
TM Goodsall, AS Day, JM Andrews… - Inflammatory Bowel …, 2024 - academic.oup.com
Background Beyond endoscopic remission, histological remission in ulcerative colitis (UC)
is predictive of clinical outcomes. Intestinal ultrasound (IUS) may offer a noninvasive …
is predictive of clinical outcomes. Intestinal ultrasound (IUS) may offer a noninvasive …
Management and treatment optimization of patients with mild to moderate ulcerative colitis
F D'Amico, E Fasulo, V Jairath… - Expert Review of …, 2024 - Taylor & Francis
Introduction Ulcerative colitis (UC) is a chronic inflammatory bowel disease with a significant
health-care burden worldwide. While medical therapy aims to induce and maintain …
health-care burden worldwide. While medical therapy aims to induce and maintain …
The assessment of segmental healing by the Modified Mayo Endoscopic Score (MMES) complements the prediction of longterm clinical outcomes in patients with …
M Lenfant, B Verstockt, J Sabino… - Alimentary …, 2024 - Wiley Online Library
Background and aims Current endoscopic scoring systems for ulcerative colitis (UC) do not
consider the extent of mucosal inflammation. The modified Mayo endoscopic score (MMES) …
consider the extent of mucosal inflammation. The modified Mayo endoscopic score (MMES) …
Higher ustekinumab levels in maintenance therapy are associated with greater mucosal healing and mucosal response in Crohn's disease: an experience of 2 IBD …
C McDonald, H Kerr, E Gibbons… - Inflammatory Bowel …, 2024 - academic.oup.com
Background Ustekinumab (UST), a human monoclonal antibody that binds the p40 subunit
of interleukin 12 (IL-12) and IL-23, is licensed for induction and maintenance therapy of …
of interleukin 12 (IL-12) and IL-23, is licensed for induction and maintenance therapy of …
Prospective Evaluation of Serum Free Thiols in Inflammatory Bowel Disease: A Candidate to Replace C-Reactive Protein for Disease Activity Assessment?
A Bohra, N Batt, K Dutt, P Sluka… - Inflammatory Bowel …, 2024 - academic.oup.com
Abstract Background Serum free thiols (SFTs) reflecting oxidative stress appear to correlate
with inflammatory bowel disease (IBD) activity. We aimed to evaluate the performance of …
with inflammatory bowel disease (IBD) activity. We aimed to evaluate the performance of …
Prevalence and outcomes of no treatment versus 5-ASA in ulcerative colitis: a nationwide analysis from the epi-IIRN
O Atia, R Magen Rimon, N Ledderman… - Inflammatory Bowel …, 2024 - academic.oup.com
Background Data regarding patients with ulcerative colitis (UC) not receiving maintenance
treatment are scarce. In this nationwide study, we aimed to explore the frequency and long …
treatment are scarce. In this nationwide study, we aimed to explore the frequency and long …
Novel and emerging drugs for the treatment of Crohn's disease: a review of phase II and III trials
P Wetwittayakhlang, T Bessissow… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Crohn's disease (CD) is a chronic inflammatory bowel disease characterized by
unpredictable flare-ups and periods of remission. While several therapeutic options, such as …
unpredictable flare-ups and periods of remission. While several therapeutic options, such as …
Histologic assessments in ulcerative colitis: the evidence behind a new endpoint in clinical trials
RK Pai, G D'Haens, T Kobayashi… - Expert Review of …, 2024 - Taylor & Francis
Introduction Treatment goals for ulcerative colitis (UC) are evolving from the achievement of
clinical remission to more rigorous goals defined by endoscopic and histologic healing …
clinical remission to more rigorous goals defined by endoscopic and histologic healing …