[HTML][HTML] Harnessing innate immune pathways for therapeutic advancement in cancer
A Hu, L Sun, H Lin, Y Liao, H Yang… - Signal Transduction and …, 2024 - nature.com
The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …
[HTML][HTML] Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies
J Zhang, S Yu, Q Peng, P Wang… - Cancer Biology & …, 2024 - ncbi.nlm.nih.gov
The intricate interplay between the human immune system and cancer development
underscores the central role of immunotherapy in cancer treatment. Within this landscape …
underscores the central role of immunotherapy in cancer treatment. Within this landscape …
TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity
A substantial fraction of cancers evade immune detection by silencing Stimulator of
Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation of this program …
Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation of this program …
Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma
Purpose: Targeting solid tumors with chimeric antigen receptor (CAR) T cells remains
challenging due to heterogenous target antigen expression, antigen escape, and the …
challenging due to heterogenous target antigen expression, antigen escape, and the …
[HTML][HTML] STING inhibitors sensitize platinum chemotherapy in ovarian cancer by inhibiting the CGAS-STING pathway in cancer-associated fibroblasts (CAFs)
J Liu, C Liu, Y Ma, X Pan, R Chu, S Yao, J Chen, C Liu… - Cancer Letters, 2024 - Elsevier
Chemotherapy resistance in ovarian cancer hampers cure rates, with cancer-associated
fibroblasts (CAFs) playing a pivotal role. Despite their known impact on cancer progression …
fibroblasts (CAFs) playing a pivotal role. Despite their known impact on cancer progression …
Harnessing natural killer cell effector function against cancer
Natural killer (NK) cells are cytotoxic innate lymphoid cells that participate in anti-tumour and
anti-viral immune responses. Their ability to rapidly destroy abnormal cells and to enhance …
anti-viral immune responses. Their ability to rapidly destroy abnormal cells and to enhance …
[HTML][HTML] A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma
J Liu, Y Lu, Y Liu, W Zhang, S Xian, S Wang, Z Zheng… - Cell & Bioscience, 2024 - Springer
Background Malignant mesothelioma is a type of infrequent tumor that is substantially
related to asbestos exposure and has a terrible prognosis. We tried to produce a fibroblast …
related to asbestos exposure and has a terrible prognosis. We tried to produce a fibroblast …
[HTML][HTML] Differential Regulation of the STING Pathway in Human Papillomavirus–Positive and-Negative Head and Neck Cancers
EL Saulters, PT Kennedy, RJ Carter, A Alsufyani… - Cancer Research …, 2024 - AACR
Squamous cell carcinomas, which arise from the cells that line the mucosal surfaces of the
head and neck, represent the most common type of head and neck cancers (HNSCC) …
head and neck, represent the most common type of head and neck cancers (HNSCC) …
[HTML][HTML] Nonpathogenic E. coli engineered to surface display cytokines as a new platform for immunotherapy
Given the safety, tumor tropism, and ease of genetic manipulation in non-pathogenic
Escherichia coli (E. coli), we designed a novel approach to deliver biologics to overcome …
Escherichia coli (E. coli), we designed a novel approach to deliver biologics to overcome …