The DNA damage response (DDR) safeguards the stable genetic information inheritance by
orchestrating a complex protein network in response to DNA damage. However, this …

The human Vitamin K Epoxide Reductase Complex (hVKORC1), a key enzyme transforming
vitamin K into the form necessary for blood clotting, requires for its activation the reducing …

Reversible protein phosphorylation is a central signaling mechanism in eukaryotes.
Although mass-spectrometry-based phosphoproteomics has become routine, identification …

Regulated protein phosphorylation controls most cellular processes. The protein
phosphatase PP1 is the catalytic subunit of many holoenzymes that dephosphorylate …

The gut microbiome interacts with the host to maintain body homeostasis, with gut microbial
dysbiosis implicated in many diseases. However, the underlying mechanisms of gut microbe …

Mass spectrometry has revolutionized cell signaling research by vastly simplifying the
analysis of many thousands of phosphorylation sites in the human proteome. Defining the …

Neuroblastoma and glioblastoma are the most commonly seen nervous system tumors, and
their treatment is challenging. Relatively safe and easy acquisition of nutraceutical natural …

The advantageous optical properties of quantum dots (QDs) motivate their use in a wide
variety of applications related to imaging and bioanalysis, including the detection of …

Hematopoietic stem cells (HSC) are primarily dormant in a cell-cycle quiescence state to
preserve their self-renewal capacity and long-term maintenance. How HSC maintain the …

Tyrosine phosphorylation is a crucial posttranslational modification that is involved in
various aspects of cell biology and often has functions in cancers. It is necessary not only to …