Specialized proresolving mediator resolvin E1 corrects the altered cystic fibrosis nasal epithelium cilia beating dynamics
M Briottet, K Sy, C London, A Aissat… - Proceedings of the …, 2024 - National Acad Sciences
In cystic fibrosis (CF), impaired mucociliary clearance leads to chronic infection and
inflammation. However, cilia beating features in a CF altered environment, consisting of …
inflammation. However, cilia beating features in a CF altered environment, consisting of …
CFTR dysfunction leads to defective bacterial eradication on cystic fibrosis airways
M Wu, JH Chen - Frontiers in Physiology, 2024 - frontiersin.org
Dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) anion
channel by genetic mutations causes the inherited disease cystic fibrosis (CF). CF lung …
channel by genetic mutations causes the inherited disease cystic fibrosis (CF). CF lung …
Interplay between environmental yielding and dynamic forcing modulates bacterial growth
AM Hancock, SS Datta - Biophysical Journal, 2024 - cell.com
Many bacterial habitats—ranging from gels and tissues in the body to cell-secreted
exopolysaccharides in biofilms—are rheologically complex, undergo dynamic external …
exopolysaccharides in biofilms—are rheologically complex, undergo dynamic external …
Cough in Non-Cystic Fibrosis Bronchiectasis
Non-cystic fibrosis bronchiectasis (NCFBE) belongs to the spectrum of chronic suppurative
lung diseases and is characterised by persistent wet/sputum-productive cough and airway …
lung diseases and is characterised by persistent wet/sputum-productive cough and airway …
TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells
OM Dunne, SL Martin, GP Sergeant, DF McAuley… - Respiratory …, 2024 - Springer
Repetitive bouts of coughing expose the large airways to significant cycles of shear stress.
This leads to the release of alarmins and the tussive agent adenosine triphosphate (ATP) …
This leads to the release of alarmins and the tussive agent adenosine triphosphate (ATP) …
Validation of TMEM16A Modulation as a Therapeutic Approach for the Treatment of Cystic Fibrosis: The Discovery of Novel TMEM16A Potentiators
H Danahay, M Gosling - Ion Channels as Targets in Drug Discovery, 2024 - Springer
The discovery of transmembrane member 16A (TMEM16A) as the molecular identity of Ca
2+-activated Cl− channels (CaCCs) has reignited interest in the modulation of these …
2+-activated Cl− channels (CaCCs) has reignited interest in the modulation of these …