Although often located at a distance from their target gene promoters, enhancers are the
primary genomic determinants of temporal and spatial transcriptional specificity in …

The dynamic spatial organization of genomes across time, referred to as the four-
dimensional nucleome (4DN), is a key component of gene regulation and biological fate …

SETDB1 is an essential histone methyltransferase that deposits histone H3 lysine 9
trimethylation (H3K9me3) to transcriptionally repress genes and repetitive elements. The …

Chromatin modifications are linked with regulating patterns of gene expression, but their
causal role and context-dependent impact on transcription remains unresolved. Here we …

Abstract CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved
protein, is known to play a critical role in chromatin structure. Post-translational modifications …

Eukaryotic gene expression is intricately regulated at multiple levels. The protein‐coding
genes are first transcribed as pre‐mRNAs in the nucleus and undergo a series of RNA …

Chronic obstructive pulmonary disease (COPD) is a group of illnesses associated with
unresolved inflammation in response to toxic environmental stimuli. Persistent exposure to …

Leukemias with ambiguous lineage comprise several loosely defined entities, often without
a clear mechanistic basis. Here, we extensively profile the epigenome and transcriptome of …

Cyanobacteria use a series of adaptation strategies and a complicated regulatory network to
maintain intracellular iron (Fe) homeostasis. Here, a global activator named IutR has been …

Ageing is a multifaceted process involving genetic and environmental interactions often
resulting in epigenetic changes, potentially leading to ageing-related diseases. Various …