Therapeutic peptides are a major class of pharmaceutical drugs owing to their target‐
binding specificity as well as their versatility in inhibiting aberrant protein‐protein …

Cognitive disorders are increasingly recognized in Parkinson disease (PD), even in early
disease stages, and memory is one of the most affected cognitive domains. Classically …

Neurodegenerative diseases are commonly classified as proteinopathies that are defined by
the aggregation of a specific protein. Parkinson's disease (PD) and dementia with Lewy …

Gingipains are protease virulence factors produced by Porphyromonas gingivalis, a Gram-
negative bacterium best known for its role in chronic periodontitis. Gingipains were recently …

α-Synuclein (α-Syn) fibrillation is a prominent contributor to neuronal deterioration and plays
a significant role in the advancement of Parkinson's Disease (PD). Considering this, the …

Abstract Multiple System Atrophy is characterized pathologically by the accumulation of
alpha-synuclein (aSyn) into glial cytoplasmic inclusions (GCIs). The mechanism underlying …

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), also known as Parkinson's disease
protein 5, is a highly expressed protein in the brain. It plays an important role in the ubiquitin …

Human γD-crystallin belongs to a crucial family of proteins known as crystallins located in
the fiber cells of the human lens. Since crystallins do not undergo any turnover after birth …

Summary α-Synuclein and LRRK2 are associated with both familial and sporadic
Parkinson's disease (PD), although the mechanistic link between these two proteins has …

Parkinson's Disease (PD) is strongly linked to the aggregation of the protein α-synuclein (α-
syn), an intrinsically disordered protein. However, strategies to combat PD by targeting the …