Sequencing and characterizing short tandem repeats in the human genome
HA Tanudisastro, IW Deveson, H Dashnow… - Nature Reviews …, 2024 - nature.com
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …
Analysis and benchmarking of small and large genomic variants across tandem repeats
Tandem repeats (TRs) are highly polymorphic in the human genome, have thousands of
associated molecular traits and are linked to over 60 disease phenotypes. However, they …
associated molecular traits and are linked to over 60 disease phenotypes. However, they …
Phenotypic Associations With the HMOX1 GT(n) Repeat in European Populations
Heme oxygenase 1 is a key enzyme in the management of heme in humans. A GT (n) repeat
length in the heme oxygenase 1 gene (HMOX1) has been widely associated with a variety of …
length in the heme oxygenase 1 gene (HMOX1) has been widely associated with a variety of …
Modification of Huntington's disease by short tandem repeats
Expansions of glutamine-coding CAG trinucleotide repeats cause a number of
neurodegenerative diseases, including Huntington's disease and several of spinocerebellar …
neurodegenerative diseases, including Huntington's disease and several of spinocerebellar …
A phenome-wide association study of tandem repeat variation in 168,554 individuals from the UK Biobank
Most genetic association studies focus on binary variants. To identify the effects of multi-
allelic variation of tandem repeats (TRs) on human traits, we performed direct TR genotyping …
allelic variation of tandem repeats (TRs) on human traits, we performed direct TR genotyping …
Repeating themes of plastic genes and therapeutic schemes targeting the 'tandem repeatome'
AJ Hannan - Brain Communications, 2024 - academic.oup.com
Repeating themes of plastic genes and therapeutic schemes targeting the ‘tandem repeatome’
| Brain Communications | Oxford Academic Skip to Main Content Advertisement intended for …
| Brain Communications | Oxford Academic Skip to Main Content Advertisement intended for …
A comparison of software for analysis of rare and common short tandem repeat (STR) variation using human genome sequences from clinical and population-based …
Short tandem repeat (STR) variation is an often overlooked source of variation between
genomes. STRs comprise about 3% of the human genome and are highly polymorphic …
genomes. STRs comprise about 3% of the human genome and are highly polymorphic …
Association between suicidal ideation and tandem repeats in contactins
K Parikh, A Quintero Reis, FR Wendt - Frontiers in psychiatry, 2024 - frontiersin.org
Background Death by suicide is one of the leading causes of death among adolescents.
Genome-wide association studies (GWAS) have identified loci that associate with suicidal …
Genome-wide association studies (GWAS) have identified loci that associate with suicidal …
Genome-wide meta-analysis of short-tandem repeats for Parkinson's disease risk using genotype imputation
O Ohlei, K Paul, SS Nielsen, D Gmelin… - Brain …, 2024 - academic.oup.com
Idiopathic Parkinson's disease is determined by a combination of genetic and environmental
factors. Recently, the first genome-wide association study on short-tandem repeats in …
factors. Recently, the first genome-wide association study on short-tandem repeats in …
Solving the Arizona search problem by imputation
E Lappo, NA Rosenberg - Iscience, 2024 - cell.com
An" Arizona search" is an evaluation of the numbers of pairs of profiles in a forensic-genetic
database that possess partial or complete genotypic matches; such a search assists in …
database that possess partial or complete genotypic matches; such a search assists in …