Sequencing and characterizing short tandem repeats in the human genome

HA Tanudisastro, IW Deveson, H Dashnow… - Nature Reviews …, 2024 - nature.com
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …

Analysis and benchmarking of small and large genomic variants across tandem repeats

AC English, E Dolzhenko, H Ziaei Jam… - Nature …, 2024 - nature.com
Tandem repeats (TRs) are highly polymorphic in the human genome, have thousands of
associated molecular traits and are linked to over 60 disease phenotypes. However, they …

Phenotypic Associations With the HMOX1 GT(n) Repeat in European Populations

F Hamilton, R Mitchell, P Ghazal… - American journal of …, 2024 - academic.oup.com
Heme oxygenase 1 is a key enzyme in the management of heme in humans. A GT (n) repeat
length in the heme oxygenase 1 gene (HMOX1) has been widely associated with a variety of …

Modification of Huntington's disease by short tandem repeats

EP Hong, EM Ramos, NA Aziz, TH Massey… - Brain …, 2024 - academic.oup.com
Expansions of glutamine-coding CAG trinucleotide repeats cause a number of
neurodegenerative diseases, including Huntington's disease and several of spinocerebellar …

A phenome-wide association study of tandem repeat variation in 168,554 individuals from the UK Biobank

C Manigbas, B Jadhav, P Garg, M Shadrina, W Lee… - medRxiv, 2024 - medrxiv.org
Most genetic association studies focus on binary variants. To identify the effects of multi-
allelic variation of tandem repeats (TRs) on human traits, we performed direct TR genotyping …

Repeating themes of plastic genes and therapeutic schemes targeting the 'tandem repeatome'

AJ Hannan - Brain Communications, 2024 - academic.oup.com
Repeating themes of plastic genes and therapeutic schemes targeting the ‘tandem repeatome’
| Brain Communications | Oxford Academic Skip to Main Content Advertisement intended for …

A comparison of software for analysis of rare and common short tandem repeat (STR) variation using human genome sequences from clinical and population-based …

JW Oketch, LV Wain, EJ Hollox - Plos one, 2024 - journals.plos.org
Short tandem repeat (STR) variation is an often overlooked source of variation between
genomes. STRs comprise about 3% of the human genome and are highly polymorphic …

Association between suicidal ideation and tandem repeats in contactins

K Parikh, A Quintero Reis, FR Wendt - Frontiers in psychiatry, 2024 - frontiersin.org
Background Death by suicide is one of the leading causes of death among adolescents.
Genome-wide association studies (GWAS) have identified loci that associate with suicidal …

Genome-wide meta-analysis of short-tandem repeats for Parkinson's disease risk using genotype imputation

O Ohlei, K Paul, SS Nielsen, D Gmelin… - Brain …, 2024 - academic.oup.com
Idiopathic Parkinson's disease is determined by a combination of genetic and environmental
factors. Recently, the first genome-wide association study on short-tandem repeats in …

Solving the Arizona search problem by imputation

E Lappo, NA Rosenberg - Iscience, 2024 - cell.com
An" Arizona search" is an evaluation of the numbers of pairs of profiles in a forensic-genetic
database that possess partial or complete genotypic matches; such a search assists in …