Dendritic cells as orchestrators of anticancer immunity and immunotherapy
I Heras-Murillo, I Adán-Barrientos, M Galán… - Nature Reviews …, 2024 - nature.com
Dendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells
that regulate adaptive immunity, including against cancer. Therefore, understanding the …
that regulate adaptive immunity, including against cancer. Therefore, understanding the …
Targeting immunogenic cell stress and death for cancer therapy
Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …
stressors, occupies a central position in the development of novel anticancer treatments …
Cancer cell metabolism and antitumour immunity
Accumulating evidence suggests that metabolic rewiring in malignant cells supports tumour
progression not only by providing cancer cells with increased proliferative potential and an …
progression not only by providing cancer cells with increased proliferative potential and an …
Decoding immunogenic cell death from a dendritic cell perspective
S Janssens, S Rennen, P Agostinis - Immunological Reviews, 2024 - Wiley Online Library
Dendritic cells (DCs) are myeloid cells bridging the innate and adaptive immune system. By
cross‐presenting tumor‐associated antigens (TAAs) liberated upon spontaneous or therapy …
cross‐presenting tumor‐associated antigens (TAAs) liberated upon spontaneous or therapy …
Macrophage-derived biomimetic nanoparticles enhanced SDT combined with immunotherapy inhibited tumor growth and metastasis
S Chen, T Ma, J Wang, S Liang, H Liao, W Tan… - Biomaterials, 2024 - Elsevier
Combination therapy based on sonodynamic therapy (SDT) combined with immune
checkpoint blockers anti-PD-L1 provides effective anti-tumor effects. We designed a …
checkpoint blockers anti-PD-L1 provides effective anti-tumor effects. We designed a …
Effects of chemotherapy on the immune system: Implications for cancer treatment and patient outcomes
A Sharma, S Jasrotia, A Kumar - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Chemotherapy is a cornerstone of cancer treatment, but it can also induce immune
suppression, which can have significant implications for patient outcomes. This review paper …
suppression, which can have significant implications for patient outcomes. This review paper …
Immunomodulatory effects and improved outcomes with cisplatin-versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer
MD Galsky, X Guan, D Rishipathak, AS Rapaport… - Cell Reports …, 2024 - cell.com
In metastatic urothelial cancer (mUC), cisplatin versus carboplatin leads to durable disease
control in a subset of patients. The IMvigor130 trial reveals more favorable effects with …
control in a subset of patients. The IMvigor130 trial reveals more favorable effects with …
Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy
C Moussion, L Delamarre - Seminars in Immunology, 2024 - Elsevier
Dendritic cells (DCs) are professional antigen-presenting cells that play a key role in
shaping adaptive immunity. DCs have a unique ability to sample their environment, capture …
shaping adaptive immunity. DCs have a unique ability to sample their environment, capture …
Determinants for antitumor and protumor effects of programmed cell death
ST Workenhe, JM Inkol, MJ Westerveld… - Cancer Immunology …, 2024 - AACR
Cytotoxic anticancer therapies activate programmed cell death in the context of underlying
stress and inflammatory signaling to elicit the emission of danger signals, cytokines, and …
stress and inflammatory signaling to elicit the emission of danger signals, cytokines, and …
Chemical conjugation mitigates immunotoxicity of chemotherapy via reducing receptor-mediated drug leakage from lipid nanoparticles
C Zheng, W Zhang, X Gong, F Xiong, L Jiang… - Science …, 2024 - science.org
Immunotoxicity remains a major hindrance to chemotherapy in cancer therapy. Nanocarriers
may alleviate the immunotoxicity, but the optimal design remains unclear. Here, we created …
may alleviate the immunotoxicity, but the optimal design remains unclear. Here, we created …