Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the
brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of …

Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …

Microglia are tissue-resident macrophages and professional phagocytes of the central
nervous system (CNS). In development, microglia-mediated phagocytosis is important for …

Autism spectrum disorder (ASD) is a major neurodevelopmental disorder affecting 1 in 36
children in the United States. While neurons have been the focus of understanding ASD, an …

Complement proteins facilitate synaptic elimination during neurodevelopmental pruning, but
neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 …

Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …

Astrocytes play an integral role in the development, maturation, and refinement of neuronal
circuits. Astrocytes secrete proteins and lipids that instruct the formation of new synapses …

Background Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as promising
chemotherapeutic drugs primarily against BRCA1/2-associated tumours, known as synthetic …

GRN mutations cause progranulin haploinsufficiency, which eventually leads to
frontotemporal dementia (FTD-GRN). PR006 is an investigational gene therapy delivering …