Update on biomarkers in renal cell carcinoma

RM Saliby, E Saad, S Kashima… - American Society of …, 2024 - ascopubs.org
Immune checkpoint inhibitors have significantly transformed the treatment paradigm for
metastatic renal cell carcinoma (RCC), offering prolonged overall survival and achieving …

Management of renal cell carcinoma: promising biomarkers and the challenges to reach the clinic

I Lyskjær, L Iisager, CT Axelsen, TK Nielsen… - Clinical Cancer …, 2024 - AACR
The incidence of renal cell carcinoma (RCC) is increasing worldwide, yet research within
this field is lagging behind other cancers. Despite increased detection of early disease as a …

Prognostic Significance of Grade Discrepancy Between Primary Tumor and Venous Thrombus in Nonmetastatic Clear-cell Renal Cell Carcinoma: Analysis of the …

Z Wu, H Chen, Q Chen, S Ge, N Yu, R Campi… - European urology …, 2024 - Elsevier
Background Further stratification of the risk of recurrence of clear-cell renal cell carcinoma
(ccRCC) with venous tumor thrombus (VTT) will facilitate selection of candidates for adjuvant …

Grading clear cell renal cell carcinoma grade using diffusion relaxation correlated MR spectroscopic imaging

Y Dai, W Hu, G Wu, D Wu, M Zhu, Y Luo… - Journal of Magnetic …, 2024 - Wiley Online Library
Background Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC,
and accurate grading is crucial for prognosis and treatment selection. Biopsy is the …

Understanding factors that influence prognosis and response to therapy in clear cell renal cell carcinoma

L Jia, LG Cowell, P Kapur - Advances in anatomic pathology, 2024 - journals.lww.com
In this review, we highlight and contextualize emerging morphologic prognostic and
predictive factors in renal cell carcinoma. We focus on clear cell renal cell carcinoma …

Treatment outcomes in patients with metastatic renal cell carcinoma with sarcomatoid and/or rhabdoid dedifferentiation after progression on immune checkpoint …

AW Hahn, DS Surasi, PV Viscuse, TK Bathala… - The …, 2024 - academic.oup.com
Background Metastatic RCC with sarcomatoid and/or rhabdoid (S/R) dedifferentiation is an
aggressive disease associated with improved response to immune checkpoint therapy (ICT) …

ctDNA predicts clinical T1a to pathological T3a upstaging after partial nephrectomy

JS Park, H Kim, WS Jang, J Kim, WS Ham… - Cancer …, 2024 - Wiley Online Library
Most patients diagnosed with clear cell renal cell carcinoma (ccRCC) are also detected with
small and organ‐confined tumors, and the majority of these are classified as clinical tumor …

Localised non‐metastatic sarcomatoid renal cell carcinoma: a 31‐year externally verified study

KA Blum, AW Silagy, A Knezevic, S Weng… - BJU …, 2024 - Wiley Online Library
Objective To evaluate post‐nephrectomy outcomes and predictors of cancer‐specific
survival (CSS) between patients with localised sarcomatoid renal cell carcinoma (sRCC) …

Predicting recurrence after radical surgery for high-risk renal cell carcinoma: development and internal validation of the “TOWARDS” score

Y Ishiyama, K Omae, T Kondo, K Yoshida… - Annals of Surgical …, 2024 - Springer
Background Considering the reported greater benefits of immunotherapy and its
unignorable adverse events in adjuvant therapy for high-risk renal cell carcinoma (hrRCC) …

[HTML][HTML] Molecular underpinnings of dedifferentiation and aggressiveness in chromophobe renal cell carcinoma

P Kapur, H Zhong, D Le, R Mukhopadhyay, J Miyata… - JCI insight, 2024 - ncbi.nlm.nih.gov
Sarcomatoid dedifferentiation is common to multiple renal cell carcinoma (RCC) subtypes,
including chromophobe RCC (ChRCC), and is associated with increased aggressiveness …