Histone H2B ubiquitylation: Connections to transcription and effects on chromatin structure

T Fetian, A Grover, KM Arndt - Biochimica et Biophysica Acta (BBA)-Gene …, 2024 - Elsevier
Nucleosomes are major determinants of eukaryotic genome organization and regulation.
Many studies, incorporating a diversity of experimental approaches, have been focused on …

[HTML][HTML] Mechanisms and Functions of the RNA Polymerase II General Transcription Machinery during the Transcription Cycle

SR Archuleta, JA Goodrich, JF Kugel - Biomolecules, 2024 - mdpi.com
Central to the development and survival of all organisms is the regulation of gene
expression, which begins with the process of transcription catalyzed by RNA polymerases …

Genome-wide regulation of Pol II, FACT, and Spt6 occupancies by RSC in Saccharomyces cerevisiae

E Biernat, M Verma, CK Govind - Gene, 2024 - Elsevier
RSC (remodels the structure of chromatin) is an essential ATP-dependent chromatin
remodeling complex in Saccharomyces cerevisiae. RSC utilizes its ATPase subunit, Sth1, to …

Ubiquitin-proteasome system regulation of a key gene regulatory factor, Paf1C

P Barman, J Ferdoush, A Kaja, P Chakraborty, B Uprety… - Gene, 2024 - Elsevier
Abstract Paf1 (Polymerase-associated factor 1) complex (Paf1C) is evolutionarily conserved
from yeast to humans, and facilitates transcription elongation as well as co-transcriptional …

[HTML][HTML] Multiple direct and indirect roles of Paf1C in elongation, splicing, and histone post-translational modifications

AM Francette, KM Arndt - bioRxiv, 2024 - ncbi.nlm.nih.gov
Paf1C is a highly conserved protein complex with critical functions during eukaryotic
transcription. Previous studies have shown that Paf1C is multi-functional, controlling specific …