Reversal of cerebral ischaemia and hypoxia and of sickness behaviour by megadose sodium ascorbate in ovine Gram-negative sepsis

CN May, CP Ow, RV Pustovit, DJ Lane, AH Jufar… - British Journal of …, 2024 - Elsevier
Background The mechanisms by which megadose sodium ascorbate improves clinical
status in experimental sepsis is unclear. We determined its effects on cerebral perfusion …

[HTML][HTML] Effects of sodium-glucose transporter-2 inhibition on systemic hemodynamics, renal function, and intra-renal oxygenation in sepsis-associated acute kidney …

AH Hulst, CPC Ow, CN May, SH Hood… - Intensive Care Medicine …, 2024 - Springer
Background People with type 2 diabetes mellitus treated with sodium-glucose transporter-2
inhibitors (SGLT2i) have lower rates of acute kidney injury (AKI). Sepsis is responsible for …

[HTML][HTML] Effect of Vasopressors and Vasodilators on Kidney Medulla Oxygenation

PM Honore, S Blackman, E Perriens… - Journal of …, 2024 - journals.lww.com
This narrative review provides a comprehensive summary of research findings up to 2023
regarding the impact of vasopressors and vasodilators on medullary oxygenation during …