The prefrontal cortex: from monkey to man

R Levy - Brain, 2024 - academic.oup.com
The prefrontal cortex is so important to human beings that, if deprived of it, our behaviour is
reduced to action-reactions and automatisms, with no ability to make deliberate decisions …

[HTML][HTML] Subcallosal area 25: Its responsivity to the stress hormone cortisol and its opposing effects on appetitive motivation in marmosets

RB Tizkar, L McIver, CM Wood, AC Roberts - Neurobiology of Stress, 2024 - Elsevier
Aberrant activity in caudal subcallosal anterior cingulate cortex (scACC) is implicated in
depression and anxiety symptomatology, with its normalisation a putative biomarker of …

Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice

ZR Zeisler, KA Heslin, FM Stoll, PR Hof, RL Clem… - Current Biology, 2024 - cell.com
Basolateral amygdala (BLA) is a key hub for affect in the brain, 1, 2, 3 and dysfunction within
this area contributes to a host of psychiatric disorders. 4, 5 BLA is extensively and …

Dissecting abstract, modality-specific and experience-dependent coding of affect in the human brain

G Lettieri, G Handjaras, EM Cappello, F Setti… - Science …, 2024 - science.org
Emotion and perception are tightly intertwined, as affective experiences often arise from the
appraisal of sensory information. Nonetheless, whether the brain encodes emotional …

Fear extinction rescuing effects of dopamine and L-DOPA in the ventromedial prefrontal cortex

SB Sartori, TMV Keil, KK Kummer, CP Murphy… - Translational …, 2024 - nature.com
The ventromedial prefrontal cortex (vmPFC; rodent infralimbic cortex (IL)), is posited to be an
important locus of fear extinction-facilitating effects of the dopamine (DA) bio-precursor, L …

Intracranial recordings of the human orbitofrontal cortical activity during self-referential episodic and valenced self-judgments

B Iravani, N Kaboodvand, JR Stieger… - Journal of …, 2024 - Soc Neuroscience
We recorded directly from the orbital (oPFC) and ventromedial (vmPFC) subregions of the
orbitofrontal cortex (OFC) in 22 (9 female, 13 male) epilepsy patients undergoing intracranial …

Scn1a haploinsufficiency in the prefrontal cortex engages to cognitive impairment and depressive phenotype

MS Riga, M Pérez-Fernández, L Miquel-Rio, V Paz… - Brain, 2024 - academic.oup.com
Altered development and function of the prefrontal cortex (PFC) during adolescence is
implicated in the origin of mental disorders. Deficits in the GABAergic system prominently …

I know why the caged bird sings: Distress tolerant individuals show greater resting state connectivity between ventromedial prefrontal cortex and right amygdala as a …

RC McIntosh, RA Hoshi, J Nomi, Z Goodman… - International Journal of …, 2024 - Elsevier
Background Intolerance to psychological distress is associated with various forms of
psychopathology, ranging from addiction to mood disturbance. The capacity to withstand …

[HTML][HTML] Lower medial prefrontal cortex connectivity with the nucleus accumbens at rest relates to HIV+ status, monocyte expression of TNF-a and perceived …

R McIntosh, A Szeto, J Lobo, M Hidalgo… - Brain, Behavior, & …, 2024 - Elsevier
Post-menopausal persons living with HIV (PWH) report elevated levels of stress and
monocyte activation compared to persons living without HIV (PWOH). Resting state …

Ventromedial frontoinsular connectivity is associated with long-term smoking behavior change in aging

N Thovinakere, M Ai, AN Colina, C Walker… - Imaging …, 2024 - direct.mit.edu
A central question in the field of cognitive aging and behavioral neuroscience is what
enables some individuals to successfully change their behavior more than others? Smoking …