Kirsten rat sarcoma virus oncogene homolog (KRAS) is the most frequently mutated
oncogene in human cancer. In colorectal cancer (CRC), KRAS mutations are present in …

From our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and
circulate throughout the body and tissues. Nucleosides and nucleotides are classically …

Importance The available evidence regarding anti–epidermal growth factor receptor (EGFR)
inhibitor rechallenge in patients with refractory circulating tumor DNA (ctDNA) …

Background The liver is the most frequent site of metastases in colorectal cancer (CRC).
This study aimed to assess the response rate and survival outcomes in metastatic CRC …

Microsatellite stable metastatic colorectal cancer (MSS mCRC; mismatch repair proficient)
has previously responded poorly to immune checkpoint blockade. Botensilimab (BOT) is an …

The current third-line (and beyond) treatment options for RAS-mutant metastatic colorectal
cancer have yielded limited efficacy. At the time of study start, the combination of sotorasib, a …

Purpose: The multi-kinase inhibitor (mKi) regorafenib has demonstrated efficacy in
chemorefractory patients with metastatic colorectal cancer (mCRC). However, lack of …

Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second
leading cause of cancer death in the United States. Management of disseminated metastatic …

Despite recent molecular and immunological advancements, prognosis of metastatic
colorectal cancer (mCRC) patients remains poor. In this context, several retrospective and …

Background Randomized clinical trials have defined the survival advantage with the
addition of biologic drugs to chemotherapy in patients with metastatic colorectal cancer …