The Role of NRF2 in Cerebrovascular Protection: Implications for Vascular Cognitive Impairment and Dementia (VCID)

Y Hu, F Zhang, M Ikonomovic, T Yang - International Journal of Molecular …, 2024 - mdpi.com
Vascular cognitive impairment and dementia (VCID) represents a broad spectrum of
cognitive decline secondary to cerebral vascular aging and injury. It is the second most …

Precise Modulation of Pericyte Dysfunction by a Multifunctional Nanoprodrug to Ameliorate Alzheimer's Disease

P Yang, Y Li, K Qian, L Zhou, Y Cheng, J Wu, M Xu… - ACS …, 2024 - ACS Publications
Pericyte dysfunction severely undermines cerebrovascular integrity and exacerbates
neurodegeneration in Alzheimer's disease (AD). However, pericyte-targeted therapy is a yet …

Exploring the multifaceted effects of Ammi visnaga: subchronic toxicity, antioxidant capacity, immunomodulatory, and anti-inflammatory activities

M Ndayambaje, H Wahnou, M Sow… - Journal of Toxicology …, 2024 - Taylor & Francis
Ammi visnaga (A. visnaga) is an annual herb that has been used in traditional medicine to
treat various ailments attributed to the presence of its bioactive compounds. The purpose of …

Developmental regulation of cellular metabolism is required for intestinal elongation and rotation

JK Grzymkowski, YC Chiu, DD Jima, BH Wyatt… - …, 2024 - journals.biologists.com
Malrotation of the intestine is a prevalent birth anomaly, the etiology of which remains poorly
understood. Here, we show that late-stage exposure of Xenopus embryos to atrazine, a …

Protective Activities of Growth Hormone-Releasing Hormone Antagonists against Toxin-Induced Endothelial Injury

S Fakir, N Barabutis - Endocrines, 2024 - mdpi.com
GHRH regulates the secretion of GH from the anterior pituitary gland, previously associated
with cancer progression and inflammation. An emerging body of evidence suggests that …

Functional transcriptome analysis revealed upregulation of MAPK-SMAD signalling pathways in chronic heat stress in crossbred cattle

G Dutta, R Alex, A Singh, GR Gowane, V Vohra… - International Journal of …, 2024 - Springer
Animal geneticists and breeders have the impending challenge of enhancing the resilience
of Indian livestock to heat stress through better selection strategies. Climate change's impact …

[HTML][HTML] Deciphering the connection: Diabetes, pericyte dysfunction, and their impact on cardiovascular health

R Chilton, EI Iranpour, Z Bloomgarden - Journal of Diabetes, 2024 - ncbi.nlm.nih.gov
In the intricate tapestry of human biology, diabetes mellitus silently threads its way, casting
unseen webs across the expanse of global health. 1 This enduring metabolic disorder …