Background Ferroptosis is a type of cell death caused by excessive iron-induced
peroxidation. It has been found to be involved in a variety of diseases, and natural products …

Ferroptosis is a newly discovered non-apoptotic and iron-dependent type of cell death.
Ferroptosis mainly takes place owing to the imbalance of anti-oxidation and oxidation in the …

Background Triple negative breast cancer (TNBC) is the most aggressive subtype of breast
cancer and exhibits high rate of chemoresistance, metastasis, and relapse. This can be …

Pancreatic cancer cells highly resistance to conventional chemo drugs, resulting low
survival rates. The aim of the study was to design and develop dual targeting polymersomes …

Bisindole alkaloids are a source of inspiration for the design and discovery of new-
generation anticancer agents. In this study, we investigated the cytotoxic and …

Cancer affects millions of people worldwide, causing death and serious health problems.
Despite significant investment in the development of new anticancer compounds, there are …

Ferroptosis is a programmed cell death mechanism characterized by the accumulation of
iron (Fe)-dependent lipid peroxides within cells. Ferroptosis holds excellent promise in …

A suitable drug delivery strategy for metallodrugs is as significant as the strategies adopted
for an efficient metallodrug design. In this study, piperlongumine, which is isolated from long …

Ferroptosis, distinct from apoptosis, is a novel cellular death pathway characterized by the
build-up of lipid peroxidation and reactive oxygen species (ROS) derived from lipids within …

Abstract Background Exportin‐1 (XPO1), a crucial protein regulating nuclear‐cytoplasmic
transport, is frequently overexpressed in various cancers, driving tumor progression and …